β-alanine derivatives and the use thereof

ABSTRACT

A compound of the general formula (I) 
                         
(wherein the symbols are as defined in the description), or a prodrug or a salt thereof.
 
     This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urinary system disease (symptom with prostatic hypertrophy or neurogenic bladder dysfunction disease, symptom to be caused by spinal cord neoplasm, nucleous hernia, spinal canal stenosis or diabetes, lower urinary tract symptom (for example, occlusion disease of lower urinary tract), inflammatory disease of lower urinary tract, polyuria), carcinoma association disease (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi&#39;s sarcoma, leucemia and carcinomatous infiltration transition), proliferative disease (disorder with aberrant angiogenesis, artery obstruction and pulmonary fibrosis), inflammation/immune system disease (psoriasis, nephropathy, hepatitis and pneumonitis symptom), disease by secretion fault (Sjogren syndrome) or brain association disease (brain infarction, cerebral apoplexy and brain or peripheral neuropathy).

TECHNICAL FIELD

The present invention relates to a β-alanine derivatives havingantagonisitic activity against lysophosphatidic acid receptor(especially EDG-2 receptor) which is useful as medicament, a process forproducting the same and the use thereof.

More specifically, the present invention relates to:

-   (1) a β-alanine derivative represented by formula (I)

(in the formula, all symbols have the same meanings as those which willbe mentioned later), a prodrug thereof, and a non-toxic salt thereof,

-   (2) a process for producing the same and-   (3) a pharmaceutical agent containing the same as an active    ingredient.

BACKGROUND OF THE INVENTION

It is known that various lipid mediators such as eicosanoid and plateletactivating factor (PAF) are produced by the activity of phospholipasefrom cell membranes.

Lysophosphatidic acid (hereinafter abbreviated as LPA) represented by

(wherein R^(A) is acyl, alkenyl or alkyl) is a lipid which is producedfrom cell membranes, acts as a mediator for signal transduction anddelivers various signals into cells. LPA that exists naturally isL-α-LPA.

Recently, the existence of three subtypes of LPA receptor has beendisclosed and it is gradually proved that their physiological activitiesare via LPA receptor. Three subtypes of LPA receptor are called EDG(Endothelial differentiation gene)-2, 4 and 7, respectively, and formpart of EDG receptor family as well as EDG-1, 3, 5, 6 and 8 that aresphingosine-1-phosphate receptor. EDG-2 is called LPA1 or VZG(Ventricular zone gene)-1, too (Mol Pharmacol 2000 December; 58(6) :1188-96). LPA receptor to which LPA binds delivers signals into cellsvia G-protein coupled to the receptor. Gs, Gi, Gq are known asG-proteins that can bind to LPA receptor, and the receptors are said torelate to the response to the action of increase or, adversely, decreaseof cell growth. Furthermore, since MAP-kinase systems operate in thedownstreams of G-proteins, it has been known that LPA receptors delivervarious signals.

Since localization of LPA receptors is different between their subtypesalthough they exist widely in living body, it is considered that therole of each receptor is different by the organ. The increase of bloodpressure in rats, and the contraction of colon in rats and ileum inguinea pigs have been known as the pharmacological activity caused byLPA (J. Pharm. Pharmacol. 1991, 43, 774, J. Pharm. Pharmacol. 1982, 34,514). In addition, the effect of LPA on urethral contraction is setforth in WO02/062389 specification and the suppressive effect of LPA onsecretion of pancreatic juice is set forth in WO03/007991 specification.

In addition, concerning to the relationship between LPA and carcinoma,until now it is known that LPA enhances the proliferation of theepithelial cancer cells originated from prostate gland (J CellularPhysiol. 1998 174, 261) and ovarian cancer cells (J. Urol. 2000, 163,1027).

In addition, it is known that LPA is related to the function of growthof various cells such as airway smooth muscle cells (Am. J. Physiol.Lung Cell Mol. Physiol., 2002, 282(1) : L91), fibroblast (Mol. CellBiol., 1998, 18(12) : 7119), mesangial cells (Clin. Science 1999, 96,431), hepatocyte, liver stellate cells (Biochem. Biophys. Res. Commun.,1998, 248, 436), vasucular smooth muscle cells (Am. J. Physiol., 1994,267 (Cell Physiol. 36) : C204), vascular endothelial cells (Am. J.Physiol. Cell Physiol., 2000, 278(3) : C612), glia cells/Schwann cells(Proc. Natl. Acad. Sci. USA, 1999, 96, 5233), adipocytes (J. Clin.Invest., 1998, 101, 1431) as well as cancer cells. In addition, it isknown that LPA is related to the function of chemotaxis of inflammatorycells as well as cancer cells besides cell growth (Biochem Biophys ResCommun., 1993, 15;193(2), 497). Moreover proliferation andcytokine-secreting activity in response to LPA of immune cells (J.Imuunol. 1999, 162, 2049), platelet aggregation activity to LPA(Biochem. Biophys. Res. Commun., 1981, 99, 391) are known. Besides, fromanalysis of knockout mouse of EDG-2 which is one of the LPA receptor,EDG-2 is concerned to be related to the brain function (Proc. Natl.Acad. Sci. USA, 2000, 97, 13384).

From these evidences, it is thought that drug antagonizing to LPAreceptor is useful for prevention and/or treatment of diseases such asvarious kinds of disease namely urinary system disease,carcinoma-associated disease, proliferative disease, inflammation/immunesystem disease, disease by secretory dysfunction or brain-associateddisease.

For example, for urinary system disease, symptom with prostatichypertrophy or neurogenic bladder dysfunction disease (such as dysuria(micturation initiation delay, extension between on urination, urinarystream very small, intermission micturation, two steps of micturation),pollakiuria, night urination, urodynia), symptom to be caused bycerebrovascular disorder, Parkinson disease, cerebral oncosis, amultiple sclerosis, Shy-Drager symptom, spinal cord neoplasm, nucleoushernia, spinal canal stenosis, diabetes, etc. (such as dysuria(micturation initiation delay, extension between on urination, urinarystream very small, intermission micturation, two steps of miction),pollakiuria, night urination, urodynia), lower urinary tract symptom(for example, occlusion disease of lower urinary tract), inflammatorydisease of lower urinary tract (such as infection), polyuria are thoughtabout.

For example, for carcinoma-related disease, solid tumor, solid tumormetastasis, angiofibroma, myeloma, multiple myeloma, Kaposi's sarcoma,leucemia are given. In solid tumor, mammary cancer, lung cancer, gastriccancer, carcinoma oesophagi, colon rectal cancer, liver cancer, ovariancancer, theca cell tumor, androblastoma, cervix cancer, endometrialcarcinoma, prostate cancer, kidney cancer, carcinoma cutaneum,osteosarcoma, pancreas cancer, urinary tract carcinoma, thyroid cancer,cerebral oncosis are given. In addition, it is thought thatcarcinomatous infiltration transition is suppressed by LPA receptorantagonist.

For example, for proliferative disease, the disease with aberrantangiogenesis are given (for example, re-arctation, diabetic retinopathy,angiogenesis-related glaucoma, crystalline lens fiber multiplicationsymptom, thyroid gland hyperplasia (including Basedow's goiter), lunginflammation, nephrotic syndrome and osteoporosis), and also arteryobstruction, pulmonary fibrosis are given.

For example, for inflammation/immune system disease, psoriasis,nephropathy (for example, IgA nephropathy), nephritis by otherinflammation/immunopathy, hepatitis, pneumonitis symptom are given.

For example, for disease by secretory dysfunction, secretory dysfunctionby autonomic nervous system dysfunction is given, for example, Sjogrensyndrome is given.

For example, for brain-related disease, brain infarction, cerebralapoplexy, brain or peripheral neuropathy are given.

In the specification of WO01/60819, it is described that the compoundrepresented by formula (B)

[wherein R^(1B) represents optionally substituted by alkyl, aryl,heterocyclic radical, alkyloxy, aryloxy, alkylthio, arylthio or halogenatom, R^(2B) represents optionally substituted by alkyl, aryl,heterocyclic radical, alkyloxy, aryloxy or halogen atom, R^(3B)represents hydrogen atom, lower alkyl or alkyl substituted by halogenatom, R^(4B) represents a radical selected from (a) optionallysubstituted by phenyl, aryl or heterocyclic radical, (b) substituted ornon-substituted alkyl or (c) substituted or non-substituted alkenyl,X^(B) represents oxygen atom or sulfur atom. With the proviso that,R^(3B) and R^(4B) may form a five- to ten-membered cyclic structuretogether with a carbon atom to which they bind, and when R^(3B) is ahydrogen atom, R^(4B) represents a group other than methyl.]

or a salt thereof have the LPA receptor antagonistic activity.

DISCLOSURE OF THE INVENTION

The inventors of the present invention have carried out intensivestudies for finding compounds which specifically binds to LPA receptorsand exerts antagonistic activity and, as a result, they have found thatβ-alanine derivatives represented by formula (I) achieve the problem toaccomplish the present invention. The present invention can becomevarious kinds of treatment of disease medicine by showing antagonism inLPA receptor. For example, the novel compound which may be preventionand/or therapeutic agent such as the urinary system disease that doesnot influence blood pressure is provided. The β-alanine derivativerepresented by formula (I) of the present invention is the novelcompound which is not known till now.

The present invention relates to:

-   (1) A β-alanine derivative represented by formula (I):

wherein A represents (1) C1˜6 alkylene, (2) C2˜6 alkenylene, or (3) C2˜6alkynylene wherein A may be substituted by 1-3 of C1˜4 alkyl;

represents (1) C3˜15 carbocyclic ring, or (2) 3-15 membered heterocyclicring containing 1-4 of nitrogen atom(s), 1-2 of oxygen atom(s) and/or1-2 of sulfur atom(s);

-   -   R¹ represents (1) C1˜4 alkyl, (2) a halogen atom, (3) cyano, (4)        trihalomethyl, (5) —OR⁶, (6) —SR⁷, (7) —NR⁸R⁹, (8) nitro, (9)        —COOR¹⁰, (10) —CONR¹¹R¹², (11) —NR¹³COR¹⁴, (12)        —SO₂NR¹⁵R¹⁶, (13) —NR¹⁷SO₂R¹⁸, (14) —S(O)R¹⁹ or (15) —SO₂R²⁰;

R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹ and R²⁰each independently represents (1) a hydrogen atom or (2) C1˜4 alkyl;

R² and R³ each independently represents (1) C1˜4 alkyl, (2) C1˜4 alkoxyor (3) a halogen atom;

R⁴ and R⁵ each independently represents (1) a hydrogen atom, (2) C1˜4alkyl, (3) C2˜4 alkenyl, (4) C2˜4 alkynyl, (5) C1˜4 alkyl substituted by—OR²¹, (6) C1˜4 alkyl substituted by —NR²²R²³ or (7)

R⁴ and R⁵ taken together with nitrogen atom to which they are attachedrepresents 3-15 membered mono-, bi- or tricyclic heterocyclic ringwherein the heterocyclic ring contains at least one nitrogen atom andmay be substituted by C1˜14 alkyl substituted by —OR²⁵;

R²¹, R²², R²³ and R²⁵ each independently represents (1) a hydrogen atom,(2) C1˜4 alkyl, (3) C2˜6 acyl or (4) trihaloacetyl;

E represents (1) single bond, (2) C1˜6 alkylene, (3) C2˜6 alkenylene or(4) C2˜6 alkynylene wherein E may be substituted by C1˜4 alkylsubstituted by 1-3 of group(s) selected from (1) C1˜4 alkyl and (2)—OR²⁶;

R²⁶ represents (1) a hydrogen atom, (2) C1˜4 alkyl, (3) C2˜6 acyl or (4)trihaloacetyl;

represents (1) C3˜15 carbocyclic ring or (2) 3-15 membered heterocyclicring containing 1-4 of nitrogen atom(s), 1-2 of oxygen atom(s) and/or1-2 of sulfur atom(s);

R²⁴ represents (1) C1˜4 alkyl, (2) a halogen atom, (3) cyano, (4)trihalomethyl, (5) —OR²⁷, (6) —SR²⁸, (7) —NR²⁹R³⁰, (8) nitro, (9)—COOR³¹, (10) —CONR³²R³³, (11) —NR³⁴COR³⁵, (12) —SO₂NR³⁶R³⁷, (13)—NR³⁸SO₂R³⁹, (14) —S(O)R⁴⁰ or (15) —SO₂R⁴¹;

R²⁷, R²⁸, R²⁹, R³⁰, R³¹, R³², R³³ R³⁴, R³⁵, R³⁶, R³⁷, R³⁸, R³⁹, R⁴⁰ andR⁴¹ each independently represents (1) a hydrogen atom or (2) C1˜4 alkyl;

i represents 0 or an integer of 1˜5;

m represents 0 or an integer of 1˜4;

n represents 0 or an integer of 1˜4;

p represents 0 or an integer of 1˜5;

wherein when i is 2 or more, plural R¹ are the same or different; when mis 2 or more, plural R² are the same or different; when n is 2 or more,plural R³ are the same or different; when p is 2 or more, plural R²⁴ arethe same or different, or a prodrug thereof or a salt thereof,

-   (2) The prodrug according to above-mentioned (1) represented by    formula (IA):

wherein R⁴² represents (1) C1˜8 alkyl or (2) C1˜8 alkyl substituted by1-2 of hydroxyl or amino, and the other symbols are the same meaning asdefined in above-mentioned (1),

-   (3) The prodrug according to above-mentioned (1) represented by    formula (IB):

wherein R⁴³ and R⁴⁴ each independently represents (1) a hydrogen atom,(2) C1˜8 alkyl or (3) C1˜8 alkyl substituted by 1-2 of hydroxyl oramino, and other symbols are the same meaning as defined inabove-mentioned (1),

-   (4) The prodrug according to above-mentioned (1) represented by    formula (IC):

wherein all other symbols are the same meaning as defined inabove-mentioned (1),

-   (5) A pharmaceutical composition comprising the compound according    to above-mentioned (1), or a prodrug thereof or a salt thereof,-   (6) The pharmaceutical composition according to above-mentioned (5),    which is a LPA receptor antagonist,-   (7) The pharmaceutical composition according to above-mentioned (6),    wherein the LPA receptor is an EDG-2 receptor,-   (8) The pharmaceutical composition according to above-mentioned (7),    which is an agent for prevention and/or treatment for urinary system    disease,-   (9) The pharmaceutical composition according to above-mentioned (7),    which is an agent for prevention and/or treatment for disease    associated with carcinoma, proliferative disease,    inflammation/immune system disease, disease by secretion fault or    disease associated with brain,-   (10) A method for prevention and/or treatment of diseases caused by    EDG-2, which comprises administering an effective amount of the    compound according to above-mentioned (1), or a prodrug thereof or a    salt thereof to a mammal,-   (11) The method for prevention and/or treatment according to    above-mentioned (10), wherein the disease caused by EDG-2 is urinary    system disease,-   (12) The method for prevention and/or treatment according to    above-mentioned (10), wherein the disease caused by EDG-2 is disease    associated with carcinoma, proliferative disease,    inflammation/immune system disease, disease by secretion fault or    disease associated with brain,-   (13) Use of the compound according to above-mentioned (1), a prodrug    thereof or a salt thereof for the manufacture of an agent for    prevention and/or treatment of diseases caused by EDG-2,-   (14) The use according to above-mentioned (13), wherein the disease    caused by EDG-2 is urinary system disease,-   (15) The use according to above-mentioned (13), wherein the disease    caused by EDG-2 is disease associated with carcinoma, proliferative    disease, inflammation/immune system disease, disease by secretion    fault or disease associated with brain,-   (16) An agent for prevention and/or treatment of urinary system    disease comprising a combination of LPA receptor antagonist    containing the compound according to above-mentioned (1) or a    prodrug thereof or a salt thereof as an active ingredient and one or    two more agent(s) selected from other LPA receptor antagonist, α1    blocking agent, anticholinergic agent, 5α-reductase inhibitor and/or    anti-androgenic agent; and-   (17) A preparation of the compound according to above-mentioned (1)    or prodrug thereof or salt thereof.

DETAILED DESCRIPTION OF THE INVENTION

In the present specification, C1-4 alkyl means methyl, ethyl, propyl,butyl and isomers thereof.

In the present specification, C1-8 alkyl means methyl, ethyl, propyl,butyl, pentyl, hexyl, heptyl, octyl and isomers thereof.

In the present specification, C2-4 alkenyl means ethenyl, propenyl,butenyl and isomers thereof.

In the present specification, C2-4 alkynyl means ethynyl, propynyl,butynyl and isomers thereof.

In the present specification, C1-4 alkoxy means methoxy, ethoxy,propoxy, butoxy and isomers thereof.

In the present specification, C1-6 alkylene means methylene, ethylene,triethylene, tetraethylene, pentaethylene, hexaethylene and isomersthereof.

In the present specification, C2-6 alkenylene means ethenylene,propenylene, butenylene, pentenylene, hexenylene and isomers thereof.

In the present specification, C2-6 alkynylene means ethynylene,propynylene, butynylene, pentynylene, hexynylene and the isomer thereof.

In the present specification, C2-6 acyl means ethanoyl, propanoyl,butanoyl, pentanoyl, hexanoyl and isomers thereof.

In the present specification, a halogen atom means such as a fluorine,chlorine, bromine and iodine atom.

In the present specification, trihalomethyl means methyl which issubstituted with three halogen atoms, such as trifluoromethyl,trichloromethyl, tribromomethyl, and triiodomethyl.

In the present specification, trihaloacetyl means acethyl which issubstituted with three halogen atoms, such as trifluoroacetyl,trichloroacetyl, tribromoacetyl and triiodoacetyl.

In the present specification, C3-15 carbocyclic ring includes C3-15mono-, bi- or tricyclic unsaturated carbocyclic ring, partiallysaturated or fully saturated carbocyclic ring, bicyclic carbocyclic ringhaving spiro bond or bicyclic bridged carbocyclic ring; for example,cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane,cyclooctane, cyclononane, cyclodecane, cycloundecane, cyclododecane,cyclotridecane, cyclotetradecane, cyclopentadecane, cyclopentene,cyclohexene, cycloheptene, cyclooctene, cyclopentadiene, cyclohexadiene,cycloheptadiene, cyclooctadiene, benzene, pentalene, perhydropentalene,azulene, perhydroazulene, indene, perhydroindene, indan, naphthalene,dihydronaphthalene, teterahydronaphthalene, perhydronaphthalene,heptalene, perhydroheptalene, biphenylene, as-indacene, s-indacene,acenaphthylene, acenaphthene, fluorene, phenalene, phenanthrene,anthracene, spiro[4.4]nonane, spiro[4.5]decane, spiro[5.5]undecane,bicyclo[2.2.1]heptane, bicyclo[2.2.1]hept-2-ene, bicyclo[3.1.1]heptane,bicyclo[3.1.1]hept-2-ene, bicyclo[2.2.2]octane, bicyclo[2.2.2]oct-2-ene,adamantane and noradamantane.

In the present specification, 3-15 membered heterocyclic ring containing1-4 of nitrogen atom(s), 1-2 of oxygen atom(s) and/or 1-2 of sulfuratom(s) includes 3-15 membered mono-, bi- or tricyclic unsaturatedheterocyclic ring, partially saturated or fully saturated heterocyclicring containing hetero atom(s) selected from 1-4 of nitrogen atom(s),1-2 of oxygen atom(s) and/or 1-2 of sulfur atom(s); for example,pyrrole, imidazole, triazole, tetrazole, pyrazole, pyridine, pyrazine,pyrimidine, pyridazine, azepine, diazepine, furan, pyran, oxepine,thiophene, thiopyran, thiepine, oxazole, isoxazole, thiazole,isothiazole, furazan, oxadiazole, oxazine, oxadiazine, oxazepine,oxadiazepine, thiadiazole, thiazine, thiadiazine, thiazepine,thiadiazepine, indole, isoindole, indolizine, benzofuran, isobenzofuran,benzothiophene, isobenzothiophene, dithianaphthalene, indazole,quinoline, isoquinoline, quinolizine, purine, phthalazine, pteridine,naphthyridine, quinoxaline, quinazoline, cinnoline, benzoxazole,benzothiazole, benzimidazole, chromene, benzoxepine, benzoxazepine,benzoxadiazepine, benzothiepine, benzothiazepine, benzothiadiazepine,benzazepine, benzodiazepine, benzofurazan, benzothiadiazole,benzotriazole, carbazole, β-carboline, acridine, phenazine,dibenzofuran, xanthene, dibenzothiophene, phenothiazine, phenoxazine,phenoxathiin, thianthrene, phenanthridine, phenanthroline, perimidine,aziridine, azetidine, pyrroline, pyrrolidine, imidazoline,imidazolidine, triazoline, triazolidine, tetrazoline, tetrazolidine,pyrazoline, pyrazolidine, dihydropyridine, tetrahydropyridine,piperidine, dihydropyrazine, tetrahydropyrazine, piperazine,dihydropyrimidine, tetrahydropyrimidine, perhydropyrimidine,dihydropyridazine, tetrahydropyridazine, perhydropyridazine,dihydroazepine, tetrahydroazepine, perhydroazepine, dihydrodiazepine,tetrahydrodiazepine, perhydrodiazepine, oxirane, oxetane, dihydrofuran,tetrahydrofuran, dihydropyran, tetrahydropyran, dihydrooxepine,tetrahydrooxepine, perhydrooxepine, thiirane, thietane,dihydrothiophene, tetrahydrothiophene, dihydrothiopyran,tetrahydrothiopyran, dihydrothiepine, tetrahydrothiepine,perhydrothiepine, dihydrooxazole, tetrahydrooxazole (oxazolidine),dihydroisoxazole, tetrahydroisoxazole (isoxazolidine), dihydrothiazole,tetrahydrothiazole (thiazolidine), dihydroisothiazole,tetrahydroisothiazole (isothiazolidine), dihydrofurazan,tetrahydrofurazan, dihydrooxadiazole, tetrahydrooxadiazole(oxadiazolidine), dihydrooxazine, tetrahydrooxazine, dihydrooxadiazine,tetrahydrooxadiazine, dihydrooxazepine, tetrahydrooxazepine,perhydrooxazepine, dihydrooxadiazepine, tetrahydrooxadiazepine,perhydrooxadiazepine, dihydrothiadiazole, tetrahydrothiadiazole(thiadiazolidine), dihydrothiazine, tetrahydrothiazine,dihydrothiadiazine, tetrahydrothiadiazine, dihydrothiazepine,tetrahydrothiazepine, perhydrothiazepine, dihydrothiadiazepine,tetrahydrothiadiazepine, perhydrothiadiazepine, morpholine,thiomorpholine, oxathiane, indoline, isoindoline, dihydrobenzofuran,perhydrobenzofuran, dihydroisobenzofuran, perhydroisobenzofuran,dihydrobenzothiophene, perhydrobenzothiophene, dihydroisobenzothiophene,perhydroisobenzothiophene, dihydroindazole, perhydroindazole,dihydroquinoline, tetrahydroquinoline, perhydroquinoline,dihydroisoquinoline, tetrahydroisoquinoline, perhydroisoquinoline,dihydrophthalazine, tetrahydrophthalazine, perhydrophthalazine,dihydronaphthyridine, tetrahydronaphthyridine, perhydronaphthyridine,dihydroquinoxaline, tetrahydroquinoxaline, perhydroquinoxaline,dihydroquinazoline, tetrahydroquinazoline, perhydroquinazoline,dihydrocinnoline, tetrahydrocinnoline, perhydrocinnoline, benzoxathiane,dihydrobenzoxazine, dihydrobenzothiazine, pyrazinomorpholine,dihydrobenzoxazole, perhydrobenzoxazole, dihydrobenzothiazole,perhydrobenzothiazole, dihydrobenzimidazole, perhydrobenzimidazole,dihydrobenzazepine, tetrahydrobenzazepine, dihydrobenzodiazepine,tetrahydrobenzodiazepine, benzodioxepane, dihydrobenzoxazepine,tetrahydrobenzoxazepine, dihydrocarbazole, tetrahydrocarbazole,perhydrocarbazole, dihydroacridine, tetrahydroacridine,perhydroacridine, dihydrodibenzofuran, dihydrodibenzothiophene,tetrahydrodibenzofuran, tetrahydrodibenzothiophene,perhydrodibenzofuran, perhydrodibenzothiophene, dioxolane, dioxane,dithiolane, dithiane, dioxaindan, benzodioxane, chroman, benzodithiolaneand benzodithiane.

In the present specification, 3-15 membered mono-, bi- or tricyclicheterocyclic ring which is represented by R⁴ and R⁵ taken together withnitrogen atom to which they are attached includes 3-15 membered mono-,bi- or tricyclic unsaturated heterocyclic ring, partially saturated orfully saturated heterocyclic ring containing at least one nitrogen atom;for example, pyrrole, imidazole, triazole, tetrazole, pyrazole, indole,isoindole, indazole, purine, benzimidazole, benzazepine, benzodiazepine,benzotriazole, carbazole, β-carboline, 1,2,3,4-tetrahydro-β-carboline,phenothiazine, phenoxazine, perimidine, aziridine, azetidine, pyrroline,pyrrolidine, imidazoline, imidazolidine, triazoline, triazolidine,tetrazoline, tetrazolidine, pyrazoline, pyrazolidine, dihydropyridine,tetrahydropyridine, piperidine, dihydropyrazine, tetrahydropyrazine,piperazine, dihydropyrimidine, tetrahydropyrimidine, perhydropyrimidine,dihydropyridazine, tetrahydropyridazine, perhydropyridazine,dihydroazepine, tetrahydroazepine, perhydroazepine, dihydrodiazepine,tetrahydrodiazepine, perhydrodiazepine, tetrahydrooxazole (oxazolidine),tetrahydroisoxazole (isoxazolidine), tetrahydrothiazole (thiazolidine),tetrahydroisothiazole (isothiazolidine), dihydrofurazan,tetrahydrofurazan, dihydrooxadiazole, tetrahydrooxadiazole(oxadiazolidine), tetrahydrooxazine, dihydrooxadiazine,tetrahydrooxadiazine, perhydrooxazepine, tetrahydrooxadiazepine,perhydrooxadiazepine, dihydrothiadiazole, tetrahydrothiadiazole(thiadiazolidine), tetrahydrothiazine, dihydrothiadiazine,tetrahydrothiadiazine, perhydrothiazepine, tetrahydrothiadiazepine,perhydrothiadiazepine, morpholine, thiomorpholine, indoline,isoindoline, dihydroindazole, perhydroindazole, dihydroquinoline,tetrahydroquinoline, perhydroquinoline, dihydroisoquinoline,tetrahydroisoquinoline, perhydroisoquinoline, dihydrophthalazine,tetrahydrophthalazine, perhydrophthalazine, dihydronaphthyridine,tetrahydronaphthyridine, perhydronaphthyridine, dihydroquinoxaline,tetrahydroquinoxaline, perhydroquinoxaline, dihydroquinazoline,tetrahydroquinazoline, perhydroquinazoline, dihydrocinnoline,tetrahydrocinnoline, perhydrocinnoline, dihydrobenzoxazine,dihydrobenzothiazine, pyrazinomorpholine, dihydrobenzoxazole,perhydrobenzoxazole, dihydrobenzothiazole, perhydrobenzothiazole,dihydrobenzimidazole, perhydrobenzimidazole, dihydrobenzazepine,tetrahydrobenzazepine, dihydrobenzodiazepine, tetrahydrobenzodiazepine,tetrahydrobenzoxazepine, dihydrocarbazole, tetrahydrocarbazole,perhydrocarbazole, dihydroacridine and perhydroacridine.

Unless otherwise specifically mentioned, all isomers are included in thepresent specification. For example, alkyl, alkenyl, alkynyl, alkoxy,alkylene, alkenylene and alkynylene include linear and branched ones.Moreover, all of isomers due to double bond, ring and fused ring (E-,Z-, cis- and trans-substances), isomers due to presence of asymmetriccarbon, etc. (R-, S-, α- and β-substances, enantiomer and diastereomer),optically active substances having optical rotation (D-, L-, d- andl-substances), polar substances by chromatographic separation(high-polar substance and low-polar substance), equilibrium compounds,rotational isomers, a mixture thereof in any proportion and a racemicmixture are included in the present invention.

Unless otherwise specifically mentioned in the present specification, asymbol

means a bond to the opposite side of the paper (i.e., α-configuration),

means a bond to this side of the paper (i.e., β-configuration) and

means a mixture of α- and β-configurations as will be obvious forpersons skilled in the art.

The compounds of the present invention are converted to non-toxic saltsby known methods. With regard to the non-toxic salts, those which arepharmaceutically acceptable and soluble in water are preferred. Examplesof appropriate salts are salt with alkaline metal (such as potassium,sodium and lithium), salt with alkaline earth metal (such as calcium andmagnesium), ammonium salt (such as tetramethylammonium salt andtetrabutylammonium salt), salt with organic amine (such astriethylamine, methylamine, dimethylamine, cyclopentylamine,benzylamine, phenethylamine, piperidine, monoethanolamine,diethanolamine, tris(hydroxymethyl)methylamine, lysine, arginine andN-methyl-D-glucamine) and acid addition salt (such as inorganic acidsalt (e.g., hydrochloride, hydrobromide, hydroiodide, sulfate, phosphateand nitrate) and organic acid salt (e.g., acetate, trifluoroacetate,lactate, tartrate, oxalate, fumarate, maleate, benzoate, citrate,methanesulfonate, ethanesulfonate, benzenesulfonate, toluenesulfonate,isothionate, glucuronate and gluconate)). The salt of the compound ofthe present invention also includes solvates and also solvates with theabove-mentioned alkaline (earth) metal salt, ammonium salt, organicamine salt and acid addition salt.

The solvate is preferably non-toxic and water-soluble. Examples of anappropriate solvate are solvates with water and with alcoholic solvent(such as ethanol).

A prodrug of the present invention is not limited in particular, but thecompound which is improved against bioavailability and permeability ofbiomembrane is preferable. Since the compound represented by formula (I)of the present invention has carboxyl group, it includes the compoundwhich is converted to carboxyl group by cleaving in vivo or by oxidationin vivo.

The compound which is converted to carboxyl group by cleaving in vivoinclude, for example, carboxylic ester derivertives represented byformula (IA) or carboxamide derivatives represented by formula (IB).

The compound which is converted to carboxyl group by oxidation in vivoincludes, for example, alcohol derivertives represented by formula (IC).

In formula (I), A is preferably C1-6 alkylene, more preferablymethylene, ethylene, trimethylene or tetramethylene.

In formula (I),

is preferably C5-10 carbocyclic ring or 5-10 membered heterocyclic ringcontaining 1-4 of nitrogen atom(s), 1-2 of oxygen atom(s) and/or 1-2 ofsulfur atom(s) and, more preferably benzene, naphthalene,tetrahydronaphthalene, indene, cyclohexane, pyridine, piperidine,quinoline, tetrahydroquinoline, pyrrole, pyrrolidine, indole, indoline,furan, benzofuran, thiophene or benzothiophene.

In formula (1), R¹ is preferably C1-4 alkyl, halogen atom, —OR⁶, —SR⁷,—NR⁸R⁹, nitro, —COOR¹⁰, —CONR¹¹R¹², —NR¹³COR¹⁴, —SO₂NR¹⁵R¹⁶ or—NR¹⁷SO₂R¹⁸ and, more preferably methyl, ethyl, propyl, butyl, fluorineatom, chlorine atom, hydroxy, methoxy, ethoxy, propoxy, aminosulfonyl ordimethylaminosulfonyl.

In formula (I), R² or R³ are preferably C1-4 alkyl or C1-4 alkoxy.

R⁴ and R⁵ are preferably hydrogen atom, C1-4 alkyl, C2-4 alkenyl, C1-4alkyl substituted by —OR²¹, C1-4 alkyl substituted by —NR²²R²³ or

and, more preferably hydrogen atom, C1-4 alkyl, allyl, hydroxymentyl,2-hydroxyethyl, 2-(dimethylamino)ethyl or

In formula (I), 3-15 membered mono-, bi- or tricyclic heterocyclic ringwhich is represented by R⁴ and R⁵ taken together with nitrogen atom towhich they are attached is preferably aziridine, azetidine, pyrroline,pyrrolidine, imidazoline, imidazolidine, pyrazoline, pyrazolidine,dihydropyridine, tetrahydropyridine, piperidine, dihydropyrazine,tetrahydropyrazine, piperazine, dihydropyrimidine, tetrahydropyrimidine,perhydropyrimidine, dihydropyridazine, tetrahydropyridazine,perhydropyridazine, dihydroazepine, tetrahydroazepine, perhydroazepine,dihydrodiazepine, tetrahydrodiazepine, perhydrodiazepine,tetrahydrooxazole (oxazolidine), tetrahydroisoxazole (isoxazolidine),tetrahydrothiazole (thiazolidine), tetrahydroisothiazole(isothiazolidine), tetrahydrooxazine, perhydrooxazepine,tetrahydrothiazine, perhydrothiazepine, morpholine, thiomorpholine,indoline, isoindoline, dihydroindazole, perhydroindazole,dihydroquinoline, tetrahydroquinoline, perhydroquinoline,dihydroisoquinoline, tetrahydroisoquinoline, perhydroisoquinoline,dihydrophthalazine, tetrahydrophthalazine, perhydrophthalazine,dihydronaphthyridine, tetrahydronaphthyridine, perhydronaphthyridine,dihydroquinoxaline, tetrahydroquinoxaline, perhydroquinoxaline,dihydroquinazoline, tetrahydroquinazoline, perhydroquinazoline,dihydrocinnoline, tetrahydrocinnoline, perhydrocinnoline,dihydrobenzoxazine, dihydrobenzothiazine, dihydrobenzoxazole,perhydrobenzoxazole, dihydrobenzothiazole, perhydrobenzothiazole,dihydrobenzimidazole, perhydrobenzimidazole, dihydrobenzazepine,tetrahydrobenzazepine, dihydrobenzodiazepine, tetrahydrobenzodiazepine,tetrahydrobenzoxazepine, dihydrocarbazole, tetrahydrocarbazole,perhydrocarbazole, dihydroacridine, perhydroacridine, carbazole,β-carboline, 1,2,3,4-tetrahydro-β-carboline, phenothiazine andphenoxazine.

In formula (I), E is preferably C1-6 alkylene or C2-6-alkenylene and,more preferably methylene, ethylene, trimethylene or tetramethylene.

In formula (I),

is preferably C5-10 carbocyclic ring or 5-10 membered heterocyclic ringcontaining 1-4 of nitrogen atom(s), 1-2 of oxygen atom(s) and/or 1-2 ofsulfur atom(s) and, more preferably benzene, naphthalene,tetrahydronaphthalene, indene, cyclohexane, pyridine, piperidine,quinoline, tetrahydroquinoline, pyrrole, pyrrolidine, indole, indoline,furan, benzofuran, thiophene or benzothiophene.

In formula (I), R²⁴ is preferably C1-4 alkyl, halogen atom, —OR²⁷,—SR²⁸, —NR²⁹R³⁰, nitro, —COOR³¹, —CONR³²R³³, —NR³⁴COR³⁵, —SO₂NR³⁶R³⁷ or—NR³⁸SO₂R³⁹ and, more preferably, methyl, ethyl, propyl, butyl, fluorineatom, chlorine atom, hydroxy, methoxy, ethoxy, propoxy, aminosulfonyl ordimethylaminosulfonyl.

i is preferably 0 or an integer of 1-3.

m is preferably 0 or an integer of 1-2.

n is preferably 0 or an integer of 1-2.

p is preferably 0 or an integer of 1-3.

Among the compounds of the present invention represented by formula (I),preferred compounds are compound represented by formula (I-A-1):

(wherein all symbols have the same meanings as described above), formula(I-A-2):

(wherein all symbols have the same meanings as described above), formula(I-A-3):

(wherein all symbols have the same meanings as described above), formula(I-A-4):

(wherein all symbols have the same meanings as described above), formula(I-A-5):

(wherein all symbols have the same meanings as described above), formula(I-A-6):

(wherein all symbols have the same meanings as described above), prodrugthereof and non-toxic salt thereof.

Concrete compounds of the present invention include compounds shown inExamples, prodrug thereof and non-toxic salts thereof.

Processes for the Preparation of the Compound of the Present Invention:

The compounds of the present invention represented by formula (I),formula (IA), formula (IB) and formula (IC) can be prepared by thefollowing processes and the processes shown in Examples.

The compound represented by formula (I) can be produced subjecting thecompound represented by formula (II)

(wherein R^(II) is protective group of carboxyl, R¹⁻¹, R²⁻¹, R³⁻¹, R⁴⁻¹,and R⁵⁻¹ are the same meanings as R¹, R², R³, R⁴ and R⁵ respectively,hydroxyl, amino or thiol in the group represented by R¹⁻¹, R²⁻¹, R³⁻¹,R⁴⁻¹ and R⁵⁻¹ is protected if necessary; and other symbols have the samemeaning as defined above) to deprotection of protective group ofcarboxyl followed by subjecting to deprotection, if necessary.

The protective group for carboxyl includes such as methyl, ethyl, allyl,t-butyl, trichloroethyl, benzyl (Bn), phenacyl, p-methoxybenzyl, trityl,2-chlorotrityl, and solid-phase support which those structures linkedand the like.

Deprotection reaction of carboxyl has been well known and its examplesare as follows.

(1) Hydrolysis with an alkali,

(2) a deprotection reaction under an acidic condition,

(3) a deprotection reaction by hydrogenolysis,

(4) a deprotection reaction using metal and

(5) a deprotection reaction using organic metal.

Those methods will be specifically illustrated as follows.

(1) A deprotection reaction using an alkali is carried out, for example,at the temperature of 0 to 40° C. using a hydroxide of alkaline metal(such as sodium hydroxide, potassium hydroxide and lithium hydroxide), ahydroxide of alkaline earth metal (such as barium hydroxide and calciumhydroxide), a carbonate (such as sodium carbonate and potassiumcarbonate), an aqueous solution thereof or a mixture thereof in anorganic solvent (such as methanol, tetrahydrofuran and dioxane).

(2) A deprotection reaction under an acidic condition is carried out,for example, at the temperature of 0 to 100° C. in an organic acid (suchas acetic acid, trifluoroacetic acid, methanesulfonic acid and p-tosylicacid), an inorganic acid (hydrochloric acid and sulfuric acid) or amixture thereof (such as hydrogen bromide/acetic acid) in an organicsolvent (such as dichloromethane, chloroform, dioxane, ethyl acetate andanisole).

(3) A deprotection reaction by hydrogenolysis is carried out, forexample, at the temperature of 0 to 200° C. in a hydrogen atmosphere ofordinary pressure or high pressure or in the presence of ammoniumformate in the presence of a catalyst (such as palladium-carbon,palladium black, palladium hydroxide, platinum oxide and Raney nickel),in a solvent (such as an ether type (e.g., tetrahydrofuran, dioxane,dimethoxyethane and diethyl ether), an alcohol type (e.g., methanol andethanol), a benzene type (e.g., benzene and toluene), a ketone type(e.g., acetone and methyl ethyl ketone), a nitrile type (e.g.,acetonitrile), an amide type (such as dimethylformamide), water, ethylacetate, acetic acid or a mixed solvent comprising two or more thereof).

(4) A deprotection reaction using metal is carried out, for example, atthe temperature of 0 to 40° C., with or without ultrasonic wave in thepresence of powdery zinc in an acidic solvent (such as buffer of aceticacid of pH 4.2 to 7.2 or mixture of the buffer and an organic solventsuch as tetrahydrofuran).

(5) A deprotection reaction using a metal complex is carried out, forexample, at the temperature of 0 to 40° C. using a metal complex such astetrakistriphenylphosphine palladium (0),bis(triphenylphosphine)palladium (II) dichloride, palladium (II) acetateand tris(triphenylphosphine)rhodium (I) chloride) in the presence orabsence of a phosphine agent (such as triphenyl phosphine) in thepresence of a trap reagent (such as tributyltin hydride, triethylsilane,dimedone, morpholine, diethylamine and pyrrolidine), an organic acid(such as acetic acid, formic acid and 2-ethylhexanoic acid) and/or anorganic acid salt (such as sodium 2-ethylhexanoate and potassium2-ethylhexanoate) in an organic solvent (such as dichloromethane,dimethylformamide, tetrahydrofuran, ethyl acetate, acetonitrile, dioxaneand ethanol), water or a mixed solvent thereof.

Besides the above-mentioned method, for example, a deprotection reactionmay be carried out by a method mentioned in “T. W Greene, ProtectiveGroups in Organic Synthesis, Wiley, New York, 1999”.

As persons skilled in the art can easily understand that the aimedcompound of the present invention is able to be easily produced by usingappropriate ones among those deprotection reactions.

The deprotection reaction of the protective group can be done by thefollowing methods.

The protective group for hydroxyl includes such as methyl, trityl,methoxymethyl (MOM), 1-ethoxyethyl (EE), methoxyethoxymethyl (MEM),2-tetrahydropyranyl (THP), trimethylsilyl (TMS), triethylsilyl (TES),t-butyldimethylsilyl (TBDMS), t-butyldiphenylsilyl (TBDPS), acetyl (Ac),pivaloyl, benzoyl, benzyl (Bn), p-methoxybenzyl, allyloxycarbonyl(Alloc) and 2,2,2-trichloroethoxycarbonyl (Troc) and the like.

The protective group of amino includes such as benzyloxycarbonyl,tert-butoxycarbonyl, allyloxycarbonyl (Alloc),1-methyl-1-(4-biphenyl)ethoxycarbonyl (Bpoc), trifluoroacetyl,9-fluorenylmethoxycarbonyl, benzyl (Bn), p-methoxybenzyl,benzyloxymethyl (BOM) and 2-(trimethylsilyl)ethoxymethyl (SEM) and thelike.

The protective group of thiol includes such as benzyl, methoxybenzyl,methoxymethyl (MOM), 2-tetrahydropyranyl (THP), diphenylmethyl andacetyl (Ac) and the like.

With regard to the protective group for hydroxyl, for amino and forthiol, there is no particular limitation to the above ones so far as itis a group which is able to be easily and selectively detached. Forexample, a deprotection reaction may be carried out by a methodmentioned in “T. W. Greene, Protective Groups in Organic Synthesis,Wiley, New York, 1999”.

Deprotection reaction of a protective group for hydroxyl, amino or thiolis known and its examples are as follows.

(1) a hydrolyzing reaction with an alkali;

(2) a deprotection reaction under an acidic condition;

(3) a deprotection reaction by hydrogenolysis;

(4) a deprotection reaction of silyl;

(5) a deprotection reaction using metal; and

(6) a deprotection reaction using an organic metal.

Those methods will be specifically illustrated as follows.

A deprotection reaction using an alkali is carried out, for example, atthe temperature of 0 to 40° C. using a hydroxide of alkaline metal (suchas sodium hydroxide, potassium hydroxide and lithium hydroxide), ahydroxide of alkaline earth metal (such as barium hydroxide and calciumhydroxide), a carbonate (such as sodium carbonate and potassiumcarbonate), an aqueous solution thereof or a mixture thereof in anorganic solvent (such as methanol, tetrahydrofuran and dioxane).

(2) A deprotection reaction under an acidic condition is carried out,for example, at the temperature of 0 to 100° C. in an organic acid (suchas acetic acid, trifluoroacetic acid, methanesulfonic acid and p-tosylicacid), an inorganic acid (hydrochloric acid and sulfuric acid) or amixture thereof (such as hydrogen bromide/acetic acid) in an organicsolvent (such as dichloromethane, chloroform, dioxane, ethyl acetate andanisole).

(3) A deprotection reaction by hydrogenolysis is carried out, forexample, at the temperature of 0 to 200° C. in a hydrogen atmosphere ofordinary pressure or high pressure or in the presence of ammoniumformate in the presence of a catalyst [such as palladium-carbon,palladium black, palladium hydroxide, platinum oxide and Raney nickel)in a solvent (such as an ether type (such as tetrahydrofuran, dioxane,dimethoxyethane and diethyl ether), an alcohol type (such as methanoland ethanol), a benzene type (such as benzene and toluene), a ketonetype (such as acetone and methyl ethyl ketone), a nitrile type (such asacetonitrile), an amide type (such as dimethylformamide), water, ethylacetate, acetic acid or a mixed solvent comprising two or more thereof].

(4) A deprotection reaction of silyl is carried out, for example, at thetemperature of 0 to 40° C. using tetrabutylammonium fluoride in anorganic solvent miscible with water (such as tetrahydrofuran andacetonitrile).

(5) A deprotection reaction using metal is carried out, for example, atthe temperature of 0 to 40° C. with or without ultrasonic wave in thepresence of powdery zinc in an acidic solvent (such as acetic acid, abuffer of pH 4.2 to 7.2 and a mixed solution of a solution thereof withan organic solvent such as tetrahydrofuran).

(6) A deprotection reaction using a metal complex is carried out, forexample, at the temperature of 0 to 40° C. using a metal complex such astetrakistriphenylphosphine palladium (0),bis(triphenylphosphine)palladium (II) dichloride, palladium (II) acetateand tris(triphenylphosphine)rhodium (I) chloride) in the presence orabsence of a phosphine agent (such as triphenyl phosphine) in thepresence of a trap reagent (such as tributyltin hydride, triethylsilane,dimedone, morpholine, diethylamine and pyrrolidine), an organic acid(such as acetic acid, formic acid and 2-ethylhexanoic acid) and/or anorganic acid salt (such as sodium 2-ethylhexanoate and potassium2-ethylhexanoate) in an organic solvent (such as dichloromethane,dimethylformamide, tetrahydrofuran, ethyl acetate, acetonitrile, dioxaneand ethanol), water or a mixed solvent thereof.

Besides the above-mentioned method, for example, a deprotection reactionmay be carried out by a method mentioned in “T. W Greene, ProtectiveGroups in Organic Synthesis, Wiley, New York, 1999”.

As persons skilled in the art can easily understand that the aimedcompound of the present invention is able to be easily produced by usingappropriate ones among those deprotection reactions.

The compound represented by formula (IA) is able to be producedsubjecting the compound represented by formula (IIA)

(wherein all symbols have the same meaning as defined above) to anesterification reaction with formula (IIB)R⁴²⁻¹—OH  (IIB)(wherein R⁴²⁻¹ is the same meaning as R⁴², hydroxyl or amino in thegroup represented by R⁴²⁻¹ is protected if necessary; and other symbolshave the same meaning as defined above) followed, by subjecting todeprotection, if necessary.

Esterification reaction has been known and its examples are

(1) a process using an acid halide,

(2) a process using a mixed acid anhydride and

(3) a process using a condensing agent.

Such processes will be specifically illustrated as follows.

(1) A process using an acid halide is carried out, for example, in sucha manner that carboxylic acid reacts with an agent for producing an acidhalide (such as oxalyl chloride and thionyl chloride) in an organicsolvent (such as chloroform, dichloromethane, diethyl ether andtetrahydrofuran) or without solvent at −20° C. to refluxing temperatureand the resulting acid halide reacts with an alcohol in the presence ofa base (such as pyridine, triethylamine, dimethylaniline,dimethylaminopyridine and diisopropylethylamine) in an inert organicsolvent (such as chloroform, dichloromethane, diethyl ether andtetrahydrofuran) at the temperature of 0 to 40° C. It is also possibleto conduct the reaction with an acid halide at 0 to 40° C. in an organicsolvent (such as dioxane and tetrahydrofuran) using an aqueous solutionof alkali (such as aqueous solution of sodium bicarbonate and an aqueoussolution of sodium hydroxide).

(2) A process using a mixed acid anhydride is carried out, for example,in such a manner that carboxylic acid is made to react with an acidhalide (such as pivaloyl chloride, tosyl chloride or mesyl chloride) orwith an acid derivative (such as ethyl chloroformate and isobutylchloroformate) at 0 to 40° C. in an organic solvent (such as chloroform,dichloromethane, diethyl ether and tetrahydrofuran) or without a solventin the presence of a base (such as pyridine, triethylamine,dimethylaniline, dimethylaminopyridine and diisopropylethylamine) andthe resulting mixed acid anhydride is made to react with an alcohol at 0to 40° C. in an organic solvent (such as chloroform, dichloromethane,diethyl ether and tetrahydrofuran).

(3) A process using a condensing agent is carried out, for example, insuch a manner that carboxylic acid and an alcohol are subjected to areaction at 0 to 40° C. with or without 1-hydroxybenztriazole (HOBt)using a condensing agent (such as 1,3-dicyclohexylcarbodiimide (DCC),1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC),1,1′-carbonyldiimidazole (CDI), 2-chloro-1-methylpyridinium iodide and1-propanephosphonic acid cyclic anhydride (PPA), etc.) in the presenceor absence of a base (such as pyridine, triethylamine, dimethylanilinand dimethylaminopyridine) in an organic solvent (such as chloroform,dichloromethane, dimethylformamide, diethyl ether and tetrahydrofuran)or without a solvent.

It is preferred that all of the reactions (1), (2) and (3) are carriedout in an atmosphere of inert gas (such as argon and nitrogen) under ananhydrous condition.

A deprotection reaction of hydroxyl, amino or thiol is able to becarried out by the same methods as those mentioned above.

The compound represented by formula (IA) is also able to be producedsubjecting the compound represented by formula (IIC)

(wherein all symbols have the same meaning as defined above) to anamidation reaction with formula (IID)

(wherein all symbols have the same meaning as defined above) followed,by subjecting to deprotection, if necessary.

Amidation reaction has been known and its examples are

(1) a process using an acid halide,

(2) a process using a mixed acid anhydride and

(3) a process using a condensing agent.

Such processes will be specifically illustrated as follows.

(1) A process using an acid halide is carried out, for example, in sucha manner that carboxylic acid reacts with an agent for producing an acidhalide (such as oxalyl chloride and thionyl chloride) in an organicsolvent (such as chloroform, dichloromethane, diethyl ether andtetrahydrofuran) or without solvent at −20° C. to refluxing temperatureand the resulting acid halide reacts with an amine in the presence of abase (such as pyridine, triethylamine, dimethylaniline,dimethylaminopyridine and diisopropylethylamine) in an inert organicsolvent (such as chloroform, dichloromethane, diethyl ether andtetrahydrofuran) at the temperature of 0 to 40° C. It is also possibleto conduct the reaction with an acid halide at 0 to 40° C. in an organicsolvent (such as dioxane and tetrahydrofuran) using an aqueous solutionof alkali (such as aqueous solution of sodium bicarbonate and an aqueoussolution of sodium hydroxide).

(2) A process using a mixed acid anhydride is carried out, for example,in such a manner that carboxylic acid is made to react with an acidhalide (such as pivaloyl chloride, tosyl chloride or mesyl chloride) orwith an acid derivative (such as ethyl chloroformate and isobutylchloroformate) at 0 to 40° C. in an organic solvent (such as chloroform,dichloromethane, diethyl ether and tetrahydrofuran) or without a solventin the presence of a base (such as pyridine, triethylamine,dimethylaniline, dimethylaminopyridine and diisopropylethylamine) andthe resulting mixed acid anhydride is made to react with an amine at 0to 40° C. in an organic solvent (such as chloroform, dichloromethane,diethyl ether and tetrahydrofuran).

(3) A process using a condensing agent is carried out, for example, insuch a manner that carboxylic acid and an amine are subjected to areaction at 0 to 40° C. with or without 1-hydroxybenztriazole (HOBt)using a condensing agent (such as 1,3-dicyclohexylcarbodiimide (DCC),1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC),1,1′-carbonyldiimidazole (CDI), 2-chloro-1-methylpyridinium iodide and1-propanephosphonic acid cyclic anhydride (PPA), etc.) in the presenceor absence of a base (such as pyridine, triethylamine, dimethylanilinand dimethylaminopyridine) in an organic solvent (such as chloroform,dichloromethane, dimethylformamide, diethyl ether and tetrahydrofuran)or without a solvent.

It is preferred that all of the reactions (1), (2) and (3) are carriedout in an atmosphere of inert gas (such as argon and nitrogen) under ananhydrous condition.

A deprotection reaction of hydroxyl or amino is able to be carried outby the same methods as those mentioned above.

The compound represented by formula (IB) is able to be producedsubjecting the compound represented by formula (IIA) to an amidationreaction with a compound represented by formula (IIE)

(wherein R⁴³⁻¹ and R⁴⁴⁻¹ have the same meanings as R⁴³ and R⁴⁴,respectively, and hydroxyl or amino in the group represented by R⁴³⁻¹and R⁴⁴⁻¹ is protected, if necessary; and other symbols have the samemeaning as defined above) followed, by subjecting to deprotection, ifnecessary.

Amidation reaction is able to be carried out by the same methods asthose mentioned above.

A deprotection reaction of hydroxyl, amino or thiol is able to becarried out by the same methods as those mentioned above.

The compound represented by formula (IC) is able to be producedsubjecting the compound represented by formula (IIA) to reductionreaction followed by subjecting to deprotection, if necessary.

The reduction reaction has been known and it is carried out, forexample, in such a manner that (1) carboxylic acid is made to react withan acid halide (such as oxalyl chloride, thionyl chloride), with an acidanhydride (such as acetic anhydride) or with an acid derivatives (suchas ethyl chloroformate, isobutyl chloroformate) at −20 to 60 degrees inan organic solvent (such as chloroform, dichloromethane, diethylether,tetrahydrofuran) or without a solvent in the presence of a base (such aspyridine, triethylamine, dimethylaniline, dimethylaminopyridine,diisopropylethylamine, N-methylmorpholine) and the resulting compound ismade to react with reducting agent (such as sodium borohydride,tetrabutylammonium borohydride, calsium borohydride) at 0 to 60 degreesin a solvent (such as methanol, tetrahydrofuran, water) or (2)carboxylic acid is made to react with a reducting agent (such asdiborane, borane-pyridine complex, borane-methyl sulfide complex,diisobutyl aluminium hydride) at −80 to 0 degrees in an organic solvent(such as tetrahydrofuran, toluene).

A deprotection reaction of hydroxyl, amino or thiol is able to becarried out by the same methods as those mentioned above.

Compounds represented by formulae (II), (IIA) and (IIC) have been knownper se or are able to be easily produced by known methods.

For example, the compounds represented by formulae (II), (IIA) and (IIC)are able to be produced by the process shown in the following reactionstep formula 1.

In the reaction step, X represents a leaving group (leaving grouprepresents such as a halogen atom, mesyloxy and tosyloxy) and othersymbols have the same meanings as those defined above.

In the above reaction step formula 1, the compounds represented byformulae (III), (IV), (VI), (VIII) and (IID) used as starting materialshave been known or able to be easily produced by known methods.

In each of the reactions mentioned in the present specification, thereaction product is able to be purified by a conventional purifyingmethod such as distillation under ordinary pressure, or high performanceliquid chromatography, thin-layer chromatography or columnchromatography using silica gel or magnesium silicate andrecrystallization. Purification may be carried out for each reaction orafter completion of some reactions.

[Toxicity]

Toxicity of the compound of the present invention represented by formula(I) is sufficiently low and it was confirmed to be sufficiently safe tobe used as pharmaceuticals.

INDUSTRIAL APPLICABILITY

[Application to Pharmaceuticals]

Since the compounds of the present invention represented by formula (I)be antagonistic to LPA receptors, they are believed to be useful forprevention and/or treatment of diseases such as various kinds of diseasenamely urinary system disease, carcinoma association disease,proliferative disease, inflammation/immune system disease, disease bysecretion fault or brain association disease.

For example, for urinary system disease, symptom with prostatichypertrophy or neurogenic bladder dysfunction disease (such as dysuria(miction initiation delay, extension between on urination, urinarystream very small, intermission miction, two steps of miction),pollakiuria, night urination, urodynia), symptom to be caused bycerebrovascular disorder, Parkinson disease, cerebral oncosis, amultiple sclerosis, Shy-Drager symptom, spinal cord neoplasm, nucleoushernia, spinal canal stenosis, diabetes, etc. (such as dysuria (mictioninitiation delay, extension between on urination, urinary stream verysmall, intermission miction, two steps of miction), pollakiuria, nighturination, urodynia), lower urinary tract symptom (for example,occlusion disease of lower urinary tract), inflammatory disease of lowerurinary tract (such as infection), polyuria are thought about.

For example, for carcinoma-related disease, solid tumor, solid tumormetastasis, angiofibroma, myeloma, multiple myeloma, Kaposi's sarcoma,leucemia are given. In solid tumor, mammary cancer, lung cancer, gastriccancer, carcinoma oesophagi, colon rectal cancer, liver cancer, ovariancancer, theca cell tumor, androblastoma, cervix cancer, endometrialcarcinoma, prostate cancer, kidney cancer, carcinoma cutaneum,osteosarcoma, pancreas cancer, urinary tract carcinoma, thyroid cancer,cerebral oncosis are given. In addition, it is thought thatcarcinomatous infiltration transition is suppressed by LPA receptorantagonist.

For example, for proliferative disease, disorder with aberrantangiogenesis (for example, re-arctation, diabetic retinopathy,angiogenesis-related glaucoma, crystalline lens fiber multiplicationsymptom, thyroid gland hyperplasia (including Basedow's goiter), lunginflammation, nephrotic syndrome and osteoporosis), artery obstruction,pulmonary fibrosis are given.

For example, for inflammation/immune system disease, psoriasis,nephropathy (for example, IgA nephropathy), nephritis by otherinflammation/immunopathy, hepatitis, pneumonitis symptom are given.

For example, for disease by secretion fault, secretion fault byautonomic nervous system anomaly is given, for example, for secretionfault by autonomic nervous system anomaly, Sjogren syndrome is given.

For example, for brain-related disease, brain infarction, cerebralapoplexy, brain or peripheral neuropathy are given.

The compound of the present invention represented by formula (I),prodrug thereof or non-toxic salt thereof may be administered as acombined preparation by combining with other pharmaceuticals for thepurpose of

1) supplementing and/or enhancing of prevention and/or treatment effectof the compound,

2) improvement in pharmacokinetics and absorption and reduction of doseof the compound

and/or

3) reduction of side effect of the compound.

The combined preparation of the compound of the present inventionrepresented by formula (I) with other pharmaceuticals may beadministered in a form of a compounded agent in which both componentsare compounded in a preparation or may be in a form in which they areadministered by means of separate preparations. The case ofadministration by means of separate preparations includes a simultaneousadministration and administrations with time difference. In the case ofadministrations with time difference, the compound of the presentinvention represented by formula (I) may be firstly administeredfollowed by administering the other pharmaceutical or the otherpharmaceutical may be administered firstly followed by administering thecompound of the present invention represented by formula (I). Methodsfor each of the administration are the same or different.

There is no particular limitation for the diseases showing preventionand/or treatment effect by the above-mentioned combined preparation, sofar as it is a disease in which the prevention and/or treatment effectof the compound of present invention represented by formula (I) aresupplemented and/or enhanced.

The other pharmaceutical for supplementing and/or enhancing theprevention and/or treatment effect of the compound of the presentinvention represented by formula (I) for urinary system disease includesother urologic disease therapeutic agent such as other LPA receptorantagonist, α1 blocking agent, anticholinergic agent, 5α-reductaseinhibitor and/or anti-androgenic agent. But anticholinergic agent isused only by case without prostatic hypertrophy. It is mainly used byremedy of pollakiuria or anischuria of case without prostatichypertrophy.

The other pharmaceutical for supplementing and/or enhancing theprevention and/or treatment effect of the compound of the presentinvention represented by formula (I) for carcinoma disease regionincludes such as other carcinoma treatment of disease agent.

The other LPA receptor antagonist includes such as methyl3-({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-5-isoxazolyl]benzyl}sulfanyl)propanoate.

The α1 blocking agent includes such as terazosin hydrochloride,Bunazosin Hydrochloride, urapidil, tamsulosin hydrochloride, doxazosinmesilate, prazosin hydrochloride, indolamine, naftopidil, alfuzosinhydrochloride and AIO-8507L.

The anticholinergic agent includes such as oxybutinin hydrochloride,bethanechol chloride, propiverine hydrochloride, propantheline bromide,methylbenactyzium bromide, scopolamine butylbromide, tolterodinetartrate, trospium chloride, Z-338, UK-112166-04, KRP-197, darifenacinand YM-905.

The 5α-reductase inhibitor includes such as finasteride and GI-998745.

The anti-androgenic agent includes such as oxendolone, osaterone acetateand bicalutamide.

The other carcinoma treatment of disease agent includes alkylating agent(such as nitrogen mustard N-oxide hydrochloride, cyclophosphamide,ifosfamide, melphalan, thiotepa, carboquone, busulfan), nitrosoureaderivative (such as nimustine hydrochloride, ranimustine), anantimetabolite (such as methotrexate, mercaptopurine,6-mercapropurinboside, fluorouracil, tegafur, UFT, carmofur,doxifluridine, cytarabine, enocitabine), anticancer antibiotics (such asactionmycin D, mitomycin C, daunorubicin hydrochloride, doxorubicinhydrochloride, aclarubicin hydrochloride, neocarzinostatin, pirarubicin,epirubicin, idarubicin, chromomycin A3, bleomycin, peplomycin sulfate),plant alkaloid (such as vinblastine sulfate, vincristine sulfate,vindesine sulfate), hormone (such as estramustine phosphate sodium,mepitiostane, epitiostanol, tamoxifen citrate, diethylstilbestrolphosphate, medroxyprogesterone acetate), immunopotentiation agent (suchas lentinan, picibanil, krestin, shizophyllan, ubenimex, interferon),others (such as L-asparaginase, procarbazine hydrochloride, mitoxantronehydrochloride, cisplatin, carboplatin).

There is no particular limitation for the ratio by weight of thecompound represented by formula (I) to other pharmaceuticals.

With regard to other pharmaceuticals, any two or more may be compoundedand administered.

With regard to other pharmaceuticals which supplement and/or enhance theprevention and/or treatment effect of the compound represented byformula (I), not only that which has been found up to now but also thatwhich will be found in future on the basis of the above-mentionedmechanism are included.

When the compound represented by formula (I) which are used in thepresent invention, or concomitant drug combined the compound representedby formula (I) with other drugs are used for the above-describedpurpose, it is usually administered systemically or topically via anoral or parenteral route.

The dose of these compounds depends on the age, weight and symptom ofthe patient, the remedial value, the administration method, thetreatment time, etc. In practice, however, these compounds areadministered orally once or several times per day each in an amount offrom 0.01 mg to 1000 mg, preferably 0.1 mg to 500 mg or more preferably0.1 mg to 300 mg per adult, parenterally once or several times per dayeach in an amount of from 0.01 mg to 500 mg, preferably 0.1 mg to 100 mgor more preferably 0.1 mg to 50 mg per adult or continuouslyadministered into vein for 1 hour to 24 hours per day.

It goes without saying that the dose of these compounds may be less thanthe aforementioned value or may need to exceed the aforementioned rangebecause the dose varies under various conditions as mentioned above.

When the compound represented by formula (I) which are used in thepresent invention, or concomitant drug combined the compound representedby formula (I) with other drugs is administered, they are used in theform of solid or liquid agent for oral administration, injection, agentfor external application, suppository, dye drops or inhalant forparenteral administration or the like.

Examples of the solid agent for oral administration include tablet,pill, capsule, powder, and pellet. Examples of the capsule include hardcapsule, and soft capsule.

In such a solid agent for internal application, one or more activematerials are used in the form of preparation produced by an ordinarymethod singly or in admixture with a vehicle (e.g., lactose, mannitol,glucose, microcrystalline cellulose, starch), binder (e.g.,hydroxypropyl cellulose, polyvinyl pyrrolidone, magnesiummetasilicoaluminate), disintegrant (e.g., calcium fibrinoglycolate),glidant (e.g., magnesium stearate), stabilizer, dissolution aid (e.g.,glutamic acid, aspartic acid) or the like. The solid agent may be coatedwith a coating agent (e.g., white sugar, gelatin, hydroxypropylcellulose, hydroxypropyl methyl cellulose phthalate) or two or morelayers. Alternatively, the solid agent may be capsulized by anabsorbable material such as gelatin.

Examples of the liquid agent for oral administration includepharmaceutically acceptable aqueous solution, suspension, emulsion,syrup, and elixir. In such a liquid agent, one or more active agents aredissolved, suspended or emulsified in a commonly used diluent (e.g.,purified water, ethanol, mixture thereof). Furthermore, such a liquidagent may comprise a wetting agent, a suspending agent, an emulsifier, asweetening agent, a flavor, a preservative, a buffer, etc.

The agent for parenteral administration may be in the form of, e.g.,ointment, gel, cream, wet compress, paste, liniment, nebula, inhalant,spray, aerosol, eye drops, collunarium or the like. These agents eachcontain one or more active materials and are prepared by any knownmethod or commonly used formulation.

The ointment is prepared by any known or commonly used formulation. Forexample, one or more active materials are titurated or dissolved in abase to prepare such an ointment. The ointment base is selected fromknown or commonly used materials. In some detail, higher aliphatic acidor higher aliphatic acid ester (e.g., adipic acid, myristic acid,palmitic acid, stearic acid, oleic acid, adipic acid ester, myristicacid ester, palmitic acid ester, stearic acid ester, oleic acid ester),wax (e.g., beeswax, whale wax, ceresin), surface active agent (e.g.,polyoxyethylenealkyletherphosphoric acid ester), higher alcohol (e.g.,cetanol, stearyl alcohol, setostearyl alcohol), silicon oil (e.g.,dimethyl polysiloxane), hydrocarbon (e.g., hydrophilic petrolatum, whitepetrolatum, purified lanolin, liquid paraffin), glycol (e.g., ethyleneglycol, diethylene glycol, propylene glycol, polyethylene glycol,macrogol), vegetable oil (e.g., castor oil, olive oil, sesame oil,turpentine oil), water, absorption accelerator and rash preventive maybe used singly or in admixture of two or more thereof. The base mayfurther comprise a humectant, a preservative, a stabilizer, anantioxidant, a perfume, etc.

The gel is prepared by any known or commonly used formulation. Forexample, one or more active materials are dissolved in a base to preparesuch a gel. The gel base is selected from known or commonly usedmaterials. For example, lower alcohol (e.g., ethanol, isopropylalcohol), gelling agent (e.g., carboxymethyl cellulose, hydroxyethylcellulose, hydroxypropyl cellulose, ethyl cellulose), neutralizing agent(e.g., triethanolamine, diisopropanolamine), surface active agent (e.g.,polyethylene glycol monostearate), gum, water, absorption accelerator,and rash preventive are used singly or in admixture of two or morethereof. The gel base may further comprise a humectant, an antioxidant,a perfume, etc.

The cream is prepared by any known or commonly used formulation. Forexample, one or more active materials are dissolved in a base to preparesuch a cream. The cream base is selected from known or commonly usedmaterials. For example, higher aliphatic acid ester, lower alcohol,hydrocarbon, polyvalent alcohol (e.g., propylene glycol, 1,3-butyleneglycol), higher alcohol (e.g., 2-hexyl decanol, cetanol), emulsifier(e.g., polyoxyethylene alkyl ether, aliphatic acid ester), water,absorption accelerator, and rash preventive are used singly or inadmixture of two or more thereof. The cream base may further comprise ahumectant, an antioxidant, a perfume, etc.

The wet compress is prepared by any known or commonly used formulation.For example, one or more active materials are dissolved in a base toprepare a kneaded mixture which is then spread over a support to preparesuch a wet compress. The wet compress base is selected from known orcommonly used materials. For example, thickening agent (e.g.,polyacrylic acid, polyvinyl pyrrolidone, gum arabic, starch, gelatin,methyl cellulose), wetting agent (e.g., urea, glycerin, propyleneglycol), filler (e.g., kaolin, zinc oxide, talc, calcium, magnesium),water, dissolution aid, tackifier, and rash preventive may be usedsingly or in admixture of two or more thereof. The wet compress base mayfurther comprise a humectant, an antioxidant, a perfume, etc.

The pasting agent is prepared by any known or commonly used formulation.For example, one or more active materials are dissolved in a base toprepare a kneaded mixture which is then spread over a support to preparesuch a pasting agent. The pasting agent base is selected from known orcommonly used materials. For example, polymer base, fat and oil, higheraliphatic acid, tackifier and rash preventive may be used singly or inadmixture of two or more thereof. The pasting agent base may furthercomprise a humectant, an antioxidant, a perfume, etc.

The liniment is prepared by any known or commonly used formulation. Forexample, one or more active materials are dissolved, suspended oremulsified in water, alcohol (e.g., ethanol, polyethylene glycol),higher aliphatic acid, glycerin, soap, emulsifier, suspending agent,etc., singly or in combination of two or more thereof, to prepare such aliniment. The liniment may further comprise a humectant, an antioxidant,a perfume, etc.

The nebula, inhalant and spray each may comprise a stabilizer such assodium hydrogensulfite and a buffer capable of providing isotonicitysuch as isotonic agent (e.g., sodium chloride, sodium citrate, citricacid). For the process for the preparation of spray, reference can bemade to U.S. Pat. Nos. 2,868,691 and 3,095,355.

The injection for parenteral administration may be in the form ofsolution, suspension, emulsion or solid injection to be dissolved orsuspended in a solvent in use. The injection is prepared by dissolving,suspending or emulsifying one or more active materials in a solvent. Assuch a solvent there may be used distilled water for injection,physiological saline, vegetable oil, alcohol such as propylene glycol,polyethylene glycol and ethanol, etc., singly or in combination. Theinjection may further comprise a stabilizer, a dissolution aid (e.g.,glutamic acid, aspartic acid, Polysolvate 80 (trade name)), a suspendingagent, an emulsifier, a soothing agent, a buffer, a preservative, etc.The injection is sterilized at the final step or prepared by an asepticprocess. Alternatively, an aseptic solid agent such as freeze-driedproduct which has previously been prepared may be rendered aseptic ordissolved in an aseptic distilled water for injection or other solventbefore use.

The eye drops for parenteral administration may be in the form ofliquid, suspension, emulsion or ointment or may be dissolved in asolvent in use.

These eye drops are prepared by any known method. For example, one ormore active materials are dissolved, suspended or emulsified in asolvent. As such a solvent for eye drops there may be used sterilizedpurified water, physiological saline and other aqueous or nonaqueoussolvents (e.g., vegetable oil), singly or in combination. The eye dropsmay comprise an isotonic agent (e.g., sodium chloride, concentratedglycerin), a buffering agent (e.g., sodium phosphate, sodium acetate), asurface active agent (e.g., Polysolvate 80 (trade name), polyoxylstearate 40, polyoxyethylene-hardened castor oil), a stabilizer (sodiumcitrate, sodium edetate), a preservative (e.g., benzalconium chloride,Paraben), etc. properly selectively as necessary. The eye drops aresterilized at the final step or prepared by an aseptic process.Alternatively, an aseptic solid agent such as freeze-dried product whichhas previously been prepared may be rendered aseptic or dissolved in anaseptic distilled water for injection or other solvent before use.

The inhalant for parenteral administration may be in the form ofaerosol, powder for inhalation or liquid for inhalation. The liquid forinhalation may be dissolved or suspended in water or other proper mediumin use.

These inhalants are prepared by an known method.

For example, the liquid for inhalation is prepared from materialsproperly selected from preservatives (e.g., benzalconium chloride,Paraben), colorants, buffering agents (e.g., sodium phosphate, sodiumacetate), isotonic agents (e.g., sodium chloride, concentratedglycerin), thickening agents (e.g., carboxyvinyl polymer), absorptionaccelerators, etc. as necessary.

The powder for inhalation is prepared from materials properly selectedfrom glidants (e.g., stearic acid and salt thereof), binders (e.g.,starch, dextrin), vehicles (e.g., lactose, cellulose), colorants,preservatives (e.g., benzalconium chloride, Paraben), absorptionaccelerators, etc., if necessary.

In order to administer the liquid for inhalation, a sprayer (e.g.,atomizer, nebulizer) is normally used. In order to administer the powderfor inhalation, a powder inhaler is normally used.

Other examples of the composition for oral administration includesublingual medication for sublingual administration, suppository forrectal administration and pessary for vaginal administration prepared byan ordinary formulation comprising one or more active materials.

Referring to the local administration of the compound represented byformula (I) of the present invention, medicament may be locallyadministered to site of disease. The form of medicament is not limitedto its administration method. The medicament may be in the form ofinjection which is administered to intramuscular, subcutaneous orarticular site, solid agent (such as embedding agent, pellet and powder)or ointment.

The extended-release preparation of the compound represented by formula(I) is not limited to its form so far as medicament can be continuouslyadministered to site of disease. The extended-release preparation may bein the form of, e.g., extended-release injection (e.g., microcapsuledpreparation, microspheric preparation, nanospheric preparation),embedding preparation (e.g., film-like preparation) or the like.

The microcapsuled preparation, microspheric preparation and nanosphericpreparation of the invention each are particulate pharmaceuticalcomposition with an in vivo degradable polymer comprising the compoundrepresented by formula (I) of the present invention, or concomitant drugcombined the compound represented by formula (I) of the presentinvention with other drugs as active components.

Examples of the in vivo degradable polymer of the invention includealiphatic acid ester polymers and copolymers thereof, polyacrylic acidesters, polyhydroxybutyric acids, polyalkylene oxalates,polyorthoesters, polycarbonates, and polyaminoacids. These compounds maybe used singly or in admixture of two or more thereof. Examples of thealiphatic acid ester polymers and copolymers thereof include polylacticacid, polyglycolic acid, polycitric acid, polymalic acid, and lacticacid-glycolic acid copolymer. These compounds may be used singly or inadmixture of two or more thereof. Besides these compounds,poly-α-cyanoacrylic acid esters, poly-β-hydroxybutyric acids,polytrimethyleneoxates, polyorthoesters, polyorthocarbonates,polyethylene carbonates, poly-γ-benzyl-L-glutamic acids andpoly-L-alanines may be used singly or in admixture of two or morethereof. Preferred among these compounds are polylactic acids,polyglycolic acids and lactic acid-glycolic acid copolymers, morepreferably lactic acid-glycolic acid copolymers.

The average molecular weight of these in vivo degradable polymers to beused in the invention is preferably from about 2,000 to 800,000, morepreferably from about 5,000 to 200,000. For example, the polylactic acidpreferably has a weight-average molecular weight of from about 5,000 to100,000, more preferably from about 6,000 to 50,000. The polylactic acidcan be synthesized according to any known preparation method per se. Inthe lactic acid-glycolic cid copolymer, the composition ratio of thelactic acid to the glycolic acid is preferably from about 100/0 to 50/50(w/w), particularly from about 90/10 to 50/50. The weight-averagemolecular weight of the lactic acid-glycolic acid copolymer ispreferably from about 5,000 to 100,000, more preferably from about10,000 to 80,000. The lactic acid-glycolic acid copolymer can besynthesized according to any known preparation method per se.

The term “weight-average molecular weight” as used herein is meant toindicate molecular weight in polystyrene equivalence determined by gelpermeation chromatography (GPC).

The aforementioned in vivo degradable polymer may be changed dependingon the intensity of pharmacological activity of the compound representedby formula (I) which are used in the present invention, or concomitantdrug combined the compound represented by formula (I) with other drugsand the desired medicines to be released so far as the aforementionedaims of the invention are accomplished. For example, the in vivodegradable polymer may be used in an amount of from about 0.2 to 10,000times, preferably from about 1 to 1,000 times, more preferably fromabout 1 to 100 times (by weight) that of the physiologically activematerial.

BEST MODE FOR CARRYING OUT THE INVENTION

The following reference examples and examples illustrate the presentinvention, but do not limit the present invention.

The solvents in the parentheses show the developing or eluting solventsand the ratios of the solvents used are by volume in chromatographicseparations or TLC. The solvents in the parentheses in NMR show thesolvents for measurement.

REFERENCE EXAMPLE 1 3-(2-(4-ethoxyphenyl)ethyl)aminopropanoic acid ethylester hydrochloride

4-ethoxyphenethylamine (2.2 g) and ethyl acrylate (1.5 g) were dissolvedin ethanol (25 ml) and the mixture was stirred at room temperature for 3days. The ethanol was removed under reduced pressure. To the obtainedresidue was added 4N Hydrogen chloride in ethyl acetate. The solvent wasremoved under reduced pressure. The obtained residue was washed withdiisopropyl ether to give the title compound (4.0 g) having thefollowing physical data.

TLC:Rf 0.89 (chloroform:methanol=9:1); NMR(DMSO-d₆):δ 9.10 (brs, 2H),7.16 (d, J=8.7 Hz, 2H), 6.87 (d, J=8.7 Hz, 2H), 4.11 (q, J=7.2 Hz, 2H),3.99 (q, J=7.2 Hz, 2H), 3.40-3.00 (m, 4H), 3.00-2.85 (m, 2H), 2.79 (t,J=7.5 Hz, 2H), 1.31 (t, J=7.2 Hz, 3H), 1.21 (t, J=7.2 Hz, 3H).

REFERENCE EXAMPLE 23-(N-((2-(2-carboxyphenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid ethyl ester

The compound (600 mg) prepared in Reference example 1, diphenicanhydride (538 mg) and trietylamine (0.85 ml) were dissolved inmethylene chloride (10 ml). The mixture was stirred at room temperatureovernight. The reaction mixture was added to a mixture of ethyl acetateand 1N hydrochloric acid. The aqueous layer was extracted with ethylacetate. These organic layers were combined and then washed with asaturated aqueous solution of sodium bicarbonate and a saturated aqueoussolution of sodium chloride, and dried over anhydrous sodium sulfate.The solvent was removed to give the title compound (837 mg) having thefollowing physical data.

TLC:Rf 0.50 (chloroform:methanol=9:1);

NMR(DMSO-d₆):δ 7.90-7.15 (m, 8H), 7.00-6.70 (m, 4H), 4.00-3.90 (m, 4H),3.80-3.00 (m, 4H), 2.60-2.00 (m, 4H), 1.35-1.05 (m, 6H).

EXAMPLE 13-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid ethyl ester

The compound (150 mg) prepared in Reference example 2, 3-picolylamine(50 mg) and 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimidehydrochloride (180 mg) were dissolved in methylene chloride (5 ml). Themixture was stirred at room temperature overnight. The reaction mixturewas added to a mixture of ethyl acetate and 1N hydrochloric acid. Theaqueous layer was extracted with ethyl acetate. These organic layer werecombined, washed with a saturated aqueous solution of sodium chloride,and dried over anhydrous sodium sulfate. The solvent was removed and theobtained residue was purified by column chromatography on silica gel(chloroform:ethyl acetate=1:2) to give the compound (147 mg) of thepresent invention having the following physical data.

TLC:Rf 0.20 (chloroform:ethyl acetate=3:2); NMR(DMSO-d₆):δ 9.00-8.10 (m,2H), 7.60-6.75 (m, 17H), 4.40-3.90 (m, 4H), 3.80-3.10 (m, 4H), 2.80-2.05(m, 4H), 1.40-1.30 (m, 3H), 1.20-1.10 (m, 3H).

EXAMPLE 1(1)˜(4)

The following compounds of the present invention were obtained in thesame procedures as a series of reactions of Reference example1→Reference example 2 using corresponding amine instead of4-ethoxyphenethylamine followed by the same manner as in Example 1 usingcorresponding amine.

EXAMPLE 1(1)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid ethyl ester

TLC:Rf 0.14 (chloroform:ethyl acetate=1:1).

EXAMPLE 1(2)3-(N-((2-(2-(benzyaminocarbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid ethyl ester

TLC:Rf 0.91 (methylene chloride:methanol=9:1); NMR(DMSO-d₆):δ 9.10-8.60(m, 1H), 7.60-6.70 (m, 17H), 4.40-3.80 (m, 6H), 3.80-3.00 (m, 4H),2.80-2.00 (m, 4H), 1.40-1.20 (m, 3H), 1.20-1.10 (m, 3H).

EXAMPLE 1(3)3-(N-((2-(2-(methylaminocarbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid ethyl ester

TLC:Rf 0.62 (methylene chloride:ethyl acetate=2:1); MASS (APCI, Pos.,40V): 503 (M+H)⁺.

EXAMPLE 1(4)3-(N-((2-(2-(benzylaminocarbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethylamino))propanoicacid ethyl ester

TLC:Rf 0.73 (methylene chloride:ethyl acetate=4:1); MASS (APCI, Pos.,40V): 535 (M+H)⁺.

EXAMPLE 23-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

The compound (110 mg) prepared in Example 1 and 1N aqueous solution ofsodium hydroxide (0.5 ml) were dissolved in a mixture of ethanol (1 ml)and tetrahydrofuran (2 ml). The mixture was stirred at room temperatureovernight. The reaction mixture was added to a mixture of ethyl acetateand 1N hydrochloric acid. The aqueous layer was extracted with ethylacetate. These organic layers were combined, washed with a saturatedaqueous solution of sodium chloride and dried over anhydrous sodiumsulfate. The solvent was removed to give the compound (77 mg) of thepresent invention having the following physical data.

TLC:Rf 0.36 (chloroform:methanol=9:1); NMR(DMSO-d₆):δ 9.00-8.30 (m, 2H),7.60-6.70 (m, 15H), 4.60-4.10 (m, 2H), 4.00-3.90 (m, 2H), 3.90-3.00 (m,4H), 2.80-2.65 (m, 2H), 2.20-2.00 (m, 2H), 1.40-1.20 (m, 3H).

EXAMPLE 2(1)˜(4)

The following compounds of the present invention were obtained in thesame manner as in Example 2 using the compounds prepared in Example1(1)˜(4) instead of the compound prepared in Example 1.

EXAMPLE 2(1)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

TLC:Rf 0.56 (chloroform:methanol=9:1); NMR(DMSO-d₆, 100 degrees):δ 8.55(brs, 1H), 8.48 (dd, J=1.2, 4.8 Hz, 1H), 8.30 (s, 1H), 7.60-6.95 (m,12H), 6.81 (d, J=8.7 Hz, 2H), 4.30-4.20 (m, 2H), 3.73 (s, 3H), 3.50 (t,J=7.5 Hz, 2H), 3.42 (t, J=7.5 Hz, 2H), 2.80-2.60 (m, 2H), 2.20-2.10 (m,2H).

EXAMPLE 2(2)3-(N-((2-(2-(benzylaminocarbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

TLC:Rf 0.67 (chloroform:methanol=9:1); NMR(DMSO-d₆):δ 9.10-8.60 (m, 1H),7.60-6.70 (m, 17H), 4.40-3.80 (m, 4H), 3.80-3.00 (m, 4H), 2.80-1.90 (m,4H), 1.40-1.20 (m, 3H).

EXAMPLE 2(3)3-(N-((2-(2-(methylaminocarbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

TLC:Rf 0.53 (chloroform:methanol=9:1); NMR(DMSO-d₆):δ 8.50-8.00 (m, 1H),7.60-6.70 (m, 12H), 4.00-3.90 (m, 2H), 3.80-3.00 (m, 4H), 2.80-2.00 (m,7H). 1.40-1.30 (m, 3H).

EXAMPLE 2(4)3-(N-((2-(2-(benzylaminocarbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

TLC:Rf 0.47 (chloroform:methanol=9:1); MASS (APCI, Neg., 40V): 505(M−H)⁻.

REFERENCE EXAMPLE 3

Polymer-supported Acrylic Acid Ester

To a suspension of a polystyrene-supported Wang resin (Argonaut,catalogue number: 800296) (1.06 mmol/g, 10.0 g) in methylene chloride(100 ml) was added N,N-diisopropylethylamine (9.17 ml) and acryloylchloride (2.58 ml) at −78 degrees under an atomosphere of argon. Themixture was stirred at room temperature for 16 hours. The resin wasfiltered off from the reaction mixture and washed with methylenechloride (150 ml×4) and N-methyl-2-pyrrolidone (100 ml×3) to givepolymer-supported acrylic acid ester.

REFERENCE EXAMPLE 4 polymer-supported3-(2-(2,5-dimethoxyphenyl)ethyl)aminopropanoic acid ester

To a solution of the compound prepared in Reference example 3 inN-methyl-2-pyrrolidone (100 ml) was added 2,5-dimethoxyphenethylamine(9.60 g). The mixture was stirred at room temperature for 26 hours. Theresin was filtered off from the reaction mixture and washed withN-methyl-2-pyrrolidone (100 ml×3) and methylene chloride (100 ml×4). Theobtained resin was dried under reduced pressure to givepolymer-supported 3-(2-(2,5-dimethoxyphenyl)ethyl)aminopropanoic acidester (13.70 g).

REFERENCE EXAMPLE 5 polymer-supported3-(N-((2-(2-carboxyphenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid ester

To a suspension of the compound (4.00 g) prepared in Reference example 4in N-methyl-2-pyrrolidone (40 ml) was added diphenic anhydride (6.93 g).The mixture was stirred at room temperature for 16 hours. The resin wasfiltered off from the reaction mixture and washed withN,N-dimethylformamide (50 ml×5) to give polymer-supported3-(N-((2-(2-carboxyphenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid ester.

REFERENCE EXAMPLE 6 polymer-supported3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid ester

To a solution of the compound prepared in Reference example 5 inN,N-dimethylformamide (40 ml) were added 4-chlorobenzylamine (3.76 ml),1-hydroxybenzotriazole monohydrate (4.73 g) andN,N-diisopropylcarbodiimide (4.84 ml). The mixture was stirred at roomtemperature for 16 hours. The resin was filtered off from the reactionmixture and washed with N,N-dimethylformamide (50 ml×3), methylenechloride (50 ml×3), methanol (50 ml×2) and methylene chloride (50 ml×2)successively to give polymer-supported3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid ester

EXAMPLE 33-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

The compound prepared in Reference example 6 was suspended in a mixedsolvent of trifluoroacetic acid and water (9:1, 40 ml). The mixture wasstirred at room temperature for 1 hour. The reaction mixture wasfiltered. The resin was washed with the mixed solvent of trifluoroaceticacid and water (9:1, 40 ml). The filtrates were combined and thenconcentrated. The residue was azeotroped with toluene (20 ml×2). Theobtained residue was purified by column chromatography on silica gel(ethyl acetate:methanol:acetic acid=100:1:0.1) to give the compound(1.106 g) of the present invention having the following physical data.

TLC:Rf 0.27 (ethyl acetate:methanol:acetic acid=100:1:0.1);NMR(DMSO-d₆):δ 12.22 (s, 1H), 9.00-8.60 (m, 1H), 7.60-7.30 (m, 5H),7.30-7.00 (m, 4H), 6.97 (m, 1H), 6.90-6.40 (m, 5H), 4.45-4.25 (m, 1H),4.23-3.90 (m, 1H), 3.80-3.10 (m, 11H), 2.78 (m, 1H), 2.49 (m, 1H), 2.08(m, 1H).

EXAMPLE 3(1)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

The compound of the present invention having the following physical datawas obtained by the same procedures as a series of reactions ofReference example 6→Example 3 using 3-pyridylmetnylamine instead of4-chlorobenzylamine, if necessary, by converting to corresponding saltsby conventional method.

Free Form:

TLC:Rf 0.57 (chloroform:methanol:acetic acid=9:1:0.5); NMR(CD₃OD):δ 8.61(m, 1H), 8.34 (br, 1H), 7.73 (m, 2H), 7.64-7.54 (m, 1H), 7.54-7.38 (m,2H), 7.38-7.20 (m, 2H), 7.16-7.02 (m, 2H), 6.86-6.74 (m, 2H), 6.74-6.60(m, 2H), 4.58 (d, J=15.3 Hz, 1H), 4.18 (d, J=15.3 Hz, 1H), 3.90-3.70 (m,1H), 3.72 (s, 3H), 3.53 (s, 3H), 3.65-3.35 (m, 2H), 2.88 (m, 2H),2.80-2.40 (br, 1H), 2.22 (t, J=7.2 Hz, 2H).

Hydrochloride:

TLC:Rf 0.18 (ethyl acetate:methanol:acetic acid=90:9:0.2);NMR(DMSO-d₆):δ 9.20-8.90 (m, 1H), 8.79 (m, 1H), 8.70-8.30 (m, 1H),8.10-7.70 (m, 2H), 7.60-6.60 (m, 1H), 4.70-4.45 (m, 1H), 4.35-4.10 (m,1H), 3.80-3.10 (m, 11H), 2.85-2.60 (m, 1H), 2.55-2.30 (m, 1H), 2.25-1.95(m, 1H).

REFERENCE EXAMPLE 7

Polymer-supported Acrylic Acid Ester

Lantern PS-Wang (trademark) (Mimotopes, code number: SPPSLHMP) (16.0μmol/Lantern, 1000 pieces) was added to methylene chloride (198 ml)under an atmosphere of argon. To the mixture were addedN,N-diisopropylethylamine (77.9 ml) and acryloyl chloride (24.4 ml) at−78 degrees. The reaction mixture was stirred at room temperature for 15hours. The solid-phase support was filtered off from the reactionmixture, washed with methylene chloride (150 ml×5) and subjected toair-drying to give polymer-supported acrylic acid ester.

REFERENCE EXAMPLE 8 Polymer-supported 3-benzylaminopropanoic Acid Ester

To a solution of benzylamine in N-methyl-2-pyrrolidone (1.0 M, 15 ml)was added the compound prepared in Reference example 7 (45 pieces, 0.72mmol). The mixture was stirred at room temperature for 16 hours. Thesolid-phase support was filtered off from the reaction mixture andwashed with N-methyl-2-pyrrolidone (20 ml×4) to give polymer-supported3-benzylaminopropanoic acid ester.

REFERENCE EXAMPLE 9 polymer-supported3-(N-((2-(2-carboxyphenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid ester

The compound prepared in Reference example 8 (1350 pieces, 21.6 mmol)was added N-methyl-2-pyrrolidone (500 ml). To the mixture was addeddiphenic anhydride (48.4 g). The mixture was stirred at 50 degrees for60 hours. The solid-phase support was filtered off from the reactionmixture, washed with N,N-dimethylformamide (500 ml×4) and methylenechloride (500 ml×3), and subjected to air-drying to givepolymer-supported3-(N-((2-(2-carboxyphenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid ester.

REFERENCE EXAMPLE 10 polymer-supported3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid ester

The compound prepared in Reference example 9 (30 pieces, 0.48 mmol) wasadded to N,N-dimethylformamide (10 ml). To the mixture were added3-methylbenzylamine (2.40 mmol), 1-hydroxybenzotriazole monohydrate (368mg) and N,N-diisopropylcarbodiimide (0.376 ml). The mixture was stirredat room temperature for 16 hours. The solid-phase support was filteredoff from the reaction mixture, washed with N,N-dimethylformamide (10ml×3) and methylene chloride (10 ml×3), and subjected to air-drying togive polymer-supported3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid ester.

EXAMPLE 43-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

The compound (1 piece, 0.016 mmol) prepared in Reference example 10 wasadded to trifluoroacetic acid (0.5 ml) and treated at room temperaturefor 1 hour. The solid-phase support was taken out, and washed withtrifluoroacetic acid (0.5 ml). The washed solution was combined and thenconcentrated to give under reduced pressure to give the compound of thepresent invention having the following physical data. The analysiscondition of high performance liquid chromatography (HPLC) is shownbelow.

-   column: Xterra (trademark) MS C₁₈, 4.6×50 mm I.D., 5 μm, 100 Å;-   flow rate: 3 mL/min;    Solvent-   A solution: 0.1% aqueous solution of trifluoroacetic acid;-   B solution: 0.1% trifluoroacetic acid in acetonitrile.

The mixture ratio of A and B was fixed in 95/5 for 0.5 minutes fromstarting of measurement. The mixture ratio of A and B was linearlychanged to 0/100 for 2.5 minutes. The mixture ratio of A and B was fixedin 0/100 for 0.5 minutes. The mixture ratio of A and B was linearlychanged to 95/5 for 0.1 minute.

HPLC retention time: 3.84 minutes; MASS data (ESI, Pos., 20V): 507(M+H)⁺.

EXAMPLE 4(1)˜(1154)

The compounds of the present invention having the following physicaldata were obtained by the same procedures as a series of reactions ofReference example 8→Reference example 9 using corresponding amineinstead of benzylamine followed by the same procedures as a series ofreactions of Reference example 10→Example 4 using corresponding amineinstead of 3-methylbenzylamine. The analysis condition of highperformance liquid chromatography (HPLC) is shown below.

HPLC Condition A

-   column: Xterra (trademark) MS C₁₈, 4.6×50 mm I.D., 5 μm, 100 Å;-   flow rate: 3 mL/min;    Solvent-   A solution: 0.1% aqueous solution of trifluoroacetic acid;-   B solution: 0.1% trifluoroacetic acid in acetonitrile.

The mixture ratio of A and B was fixed in 95/5 for 0.5 minutes fromstarting of measurement. The mixture ratio of A and B was linearlychanged to 0/100 for 2.5 minutes. The mixture ratio of A and B was fixedin 0/100 for 0.5 minutes. The mixture ratio of A and B was linearlychanged to 95/5 for 0.1 minute.

HPLC Condition B

-   column: Phenomenex Max-RP, 2×50 mm I.D., 4 μm, 80 Å;-   flow rate: 250 μL/min;    Solvent-   A solution: 0.05% aqueous solution of formic acid;-   B solution: 0.05% formic acid in acetonitrile.

The mixture ratio of A and B was fixed in 95/5 at the time of ameasurement start. The mixture ratio of A and B was linearly changed to20/80 for 3.5 minutes. The mixture ratio of A and B was linearly changedto 10/90 for 0.5 minutes. The mixture ratio of A and B was fixed in10/90 for 0.8 minutes. The mixture ratio of A and B was linearly changedto 95/5 for 1 minute.

EXAMPLE 4(1)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 586 (M+H)⁺.

EXAMPLE 4(2)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(3)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 572 (M+H)⁺.

EXAMPLE 4(4)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 596 (M+H)⁺, 214.

EXAMPLE 4(5)3-(N-((2-(2-((1,2,3,4-tetrahydro-β-carbolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(6)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(7)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(8)3-(N-((2-(2-((pyridin-4-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺, 439.

EXAMPLE 4(9)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 572 (M+H)⁺.

EXAMPLE 4(10)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 560 (M+H)⁺.

EXAMPLE 4(11)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 546 (M+H)⁺.

EXAMPLE 4(12)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(13)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 560 (M+H)⁺.

EXAMPLE 4(14)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(15)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 580 (M+H)⁺, 214.

EXAMPLE 4(16)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(17)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 560 (M+H)⁺.

EXAMPLE 4(18)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 560 (M+H)⁺.

EXAMPLE 4(19)3-(N-((2-(2-((N-isopropyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 588 (M+H)⁺.

EXAMPLE 4(20)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 574 (M+H)⁺, 360.

EXAMPLE 4(21)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 602 (M+H)⁺, 388, 214.

EXAMPLE 4(22)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 602 (M+H)⁺.

EXAMPLE 4(23)3-(N-((2-(2-(((5-methyl-2-furyl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺, 214.

EXAMPLE 4(24)3-(N-((2-(2-((1-phenyl-3-trifluoroacetoxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.98 minutes; MASSdata (ESI, Pos., 20V): 686 (M+H)⁺.

EXAMPLE 4(25)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(26)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(27)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.79 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(28)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(29)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 580 (M+H)⁺.

EXAMPLE 4(30)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(31)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indo-1-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 496 (M+H)⁺.

EXAMPLE 4(32)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(33)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 580 (M+H)⁺.

EXAMPLE 4(34)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(35)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 574 (M+H)⁺.

EXAMPLE 4(36)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 578 (M+H)⁺.

EXAMPLE 4(37)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺, 214.

EXAMPLE 4(38)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.48 minutes; MASSdata (ESI, Pos., 20V): 602 (M+H)⁺; HPLC retention time: 3.62 minutes;MASS data (ESI, Pos., 20V): 602 (M+H)⁺, 498.

EXAMPLE 4(39)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 560 (M+H)⁺.

EXAMPLE 4(40)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(41)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 575 (M+H)⁺.

EXAMPLE 4(42)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(43)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(1H-indol-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 560 (M+H)⁺.

EXAMPLE 4(44)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(45)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(46)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(47)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(48)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(49)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(50)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(51)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(52)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(53)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(54)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(55)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(56)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(57)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(58)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(59)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(60)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(61)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(62)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(63)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.11 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(64)3-(N-((2-(2-(((5-methyl-2-furyl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(65)3-(N-((2-(2-((1-phenyl-3-trifluoroacetoxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.05 minutes; MASSdata (ESI, Pos., 20V): 707 (M+H)⁺.

EXAMPLE 4(66)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(67)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(68)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(69)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(70)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(71)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(72)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 517 (M+H)⁺.

EXAMPLE 4(73)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(74)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(75)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(76)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(77)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(78)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(79)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(80)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(81)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(82)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 596 (M+H)⁺.

EXAMPLE 4(83)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.45 minutes; MASSdata (ESI, Pos., 20V): 638 (M+H)⁺.

EXAMPLE 4(84)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,3-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(85)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 548 (M+H)⁺.

EXAMPLE 4(86)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.03 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(87)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.00 minutes; MASSdata (ESI, Pos., 20V): 498 (M+H)⁺.

EXAMPLE 4(88)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺.

EXAMPLE 4(89)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 558 (M+H)⁺.

EXAMPLE 4(90)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.72 minutes; MASSdata (ESI, Pos., 20V): 509 (M+H)⁺, 255.

EXAMPLE 4(91)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.68 minutes; MASSdata (ESI, Pos., 20V): 509 (M+H)⁺, 255.

EXAMPLE 4(92)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺.

EXAMPLE 4(93)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(94)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(95)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(96)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(97)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(98)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(99)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(100)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(101)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(102)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(103)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.38 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(104)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(105)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(106)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.00 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(107)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(108)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(109)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.92 minutes; MASSdata (ESI, Pos., 20V): 458 (M+H)⁺.

EXAMPLE 4(110)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(111)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(112)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.98 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(113) 3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(114)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 540 (M+H)⁺.

EXAMPLE 4(115)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.07 minutes; MASSdata (ESI, Pos., 20V): 514 (M+H)⁺.

EXAMPLE 4(116)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.07 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺, 283.

EXAMPLE 4(117)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(118)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(119)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.74 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺, 432, 269.

EXAMPLE 4(120)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.92 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺, 290, 267.

EXAMPLE 4(121)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(122)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(123)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(124)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(125)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(126)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(127)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(128)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(129)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(130)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(131)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(132)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(133)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(134)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(135)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(136)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(137)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(138)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.34 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(139)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(140)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.21 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(141)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.22 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(142)3-(N-((2-(2-(((5-methyl-2-furyl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(143)3-(N-((2-(2-((1-phenyl-3-trifluoroacetoxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.16 minutes; MASSdata (ESI, Pos., 20V): 661 (M+H)⁺.

EXAMPLE 4(144)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(145)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(146)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(147)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(148)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(149)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(150)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 471 (M+H)⁺.

EXAMPLE 4(151)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(152)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(153)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(154)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(155)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(156)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(157)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(158)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(159)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(160)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(161)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 592 (M+H)⁺.

EXAMPLE 4(162)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(163)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(164)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(165)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(166)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(167)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(168)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(169)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(170)3-(N-((2-(2-((N-(isopropyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺, 571.

EXAMPLE 4(171)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(172)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(173)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.11 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(174)3-(N-((2-(2-(((5-methyl-2-furyl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(175)3-(N-((2-(2-((1-phenyl-3-trifluoroacetoxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 699 (M+Na)+, 677 (M+H)⁺.

EXAMPLE 4(176)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(177)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(178)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(179)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(180)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(181)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(182)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(183)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(184)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(185)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(186)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenylphenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(187)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 566 (M+H)⁺.

EXAMPLE 4(188)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.45 minutes; MASSdata (ESI, Pos., 20V): 608 (M+H)⁺.

EXAMPLE 4(189)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(190)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(191)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(192)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 503 (M+H)⁺.

EXAMPLE 4(193)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(194)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(195)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 514 (M+H)⁺.

EXAMPLE 4(196)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 514 (M+H)⁺.

EXAMPLE 4(197)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(198)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(199)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.79 minutes; MASSdata (ESI, Pos., 20V): 513 (M+H)⁺.

EXAMPLE 4(200)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(201)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(202)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(203)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(204)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(205)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(206)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(207)3-(N-((2-(2-((N-(isopropyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(208)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(209)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(210)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(211)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(212)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 531 (M+H)⁺.

EXAMPLE 4(213)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 531 (M+H)⁺.

EXAMPLE 4(214)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(215)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(216)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(217)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 531 (M+H)⁺, 156.

EXAMPLE 4(218)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 463 (M+H)⁺.

EXAMPLE 4(219)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(220)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(221)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(222)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(223)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 545 (M+H)⁺.

EXAMPLE 4(224)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 519 (M+H)⁺.

EXAMPLE 4(225)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.63 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(226)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(227)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(228)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(229)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 584 (M+H)⁺.

EXAMPLE 4(230)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-thienyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(231)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺.

EXAMPLE 4(232)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.07 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(233)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(234)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.70 minutes; MASSdata (ESI, Pos., 20V): 989 (2M+H)⁺, 495 (M+H)⁺, 248.

EXAMPLE 4(235)3-(N-((2-(2-((pyridin-4-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.70 minutes; MASSdata (ESI, Pos., 20V): 989 (2M+H)⁺, 495 (M+H)⁺, 248.

EXAMPLE 4(236)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(237)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(238)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 528 (M+H)⁺.

EXAMPLE 4(239)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(240)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.42 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(241)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.42 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(242)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.01 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(243)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 530 (M+H)⁺.

EXAMPLE 4(244)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.00 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(245)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 528 (M+H)⁺.

EXAMPLE 4(246)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 528 (M+H)⁺.

EXAMPLE 4(247)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.00 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(248)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(249)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(250)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(251)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.17 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(252)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 530 (M+H)⁺.

EXAMPLE 4(253)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.76 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺, 262.

EXAMPLE 4(254)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.94 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺, 283.

EXAMPLE 4(255)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(256)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(257)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(258)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 511 (M+H)⁺.

EXAMPLE 4(259)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(260)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(261)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.29 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(262)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(263)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(264)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(265)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(266)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(267)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(268)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.01 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(269)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(270)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(271)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(272)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(273)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.19 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(274)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.22 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(275)3-(N-((2-(2-((1-phenyl-3-trifluoroacetoxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 661 (M+H)⁺.

EXAMPLE 4(276)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(277)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(278)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(279)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(280)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(281)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(282)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 471 (M+H)⁺.

EXAMPLE 4(283)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(284)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(285)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(286)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(287)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(288)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(289)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺; HPLC retention time: 3.75 minutes;MASS data (ESI, Pos., 20V): 577 (M+H)⁺, 473.

EXAMPLE 4(290)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(291)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(292)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.29 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(293)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 592 (M+H)⁺.

EXAMPLE 4(294)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(295)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 548 (M+H)⁺.

EXAMPLE 4(296)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.07 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(297)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 558 (M+H)⁺.

EXAMPLE 4(298)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(299)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(300)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(301)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.29 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(302)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.45 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(303)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.42 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(304)3-(N-((2-(2-(((5-methyl-2-furyl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 512 (M+H)⁺.

EXAMPLE 4(305)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.01 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(306)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(307)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.00 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(308)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(309)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.01 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(310)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(311)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 540 (M+H)⁺.

EXAMPLE 4(312)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.96 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺, 282; HPLC retention time: 3.08minutes; MASS data (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(313)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(314)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.74 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺, 432, 269.

EXAMPLE 4(315)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.92 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺, 290, 267.

EXAMPLE 4(316)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(317)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(318)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(319)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(320)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(321)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(322)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.07 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(323)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺, 358.

EXAMPLE 4(324)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(325)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(326)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(327)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(328)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(329)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.79 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(330)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(331)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(332)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺, 346.

EXAMPLE 4(333)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺, 360.

EXAMPLE 4(334)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺, 388.

EXAMPLE 4(335)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺, 388.

EXAMPLE 4(336)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(337)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(338)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(339)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(340)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(341)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(342)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(343)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 517 (M+H)⁺.

EXAMPLE 4(344)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(345)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.79 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(346)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(347)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(348)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(349)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(350)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.42 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺, 388; HPLC retention time: 3.53minutes; MASS data (ESI, Pos., 20V): 623 (M+H)⁺, 519.

EXAMPLE 4(351)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(352)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(353)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 596 (M+H)⁺.

EXAMPLE 4(354)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(355)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 575 (M+H)⁺.

EXAMPLE 4(356)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(357)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(358)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(359)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(360)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(361)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-3-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(362)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(363)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.26 minutes; MASSdata (ESI, Pos., 20V): 591 (M+H)⁺.

EXAMPLE 4(364)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.22 minutes; MASSdata (ESI, Pos., 20V): 591 (M+H)⁺.

EXAMPLE 4(365)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(366)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(367)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(368)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(369)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(370)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(371)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(372)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(373)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(374)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 591 (M+H)⁺; HPLC retention time: 3.80 minutes;MASS data (ESI, Pos., 20V): 591 (M+H)⁺, 487.

EXAMPLE 4(375)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(376)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(377)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 606 (M+H)⁺.

EXAMPLE 4(378)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(379)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(380)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(381)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(382)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(383)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.31 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(384)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(385)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(386)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(387)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(388)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(389)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(390)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(391)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.17 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(392)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(393)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(394)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(395)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(396)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(397)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(398)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(399)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(400)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(401)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(402)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(403)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺; HPLC retention time: 3.71 minutes;MASS data (ESI, Pos., 20V): 593 (M+H)⁺, 489.

EXAMPLE 4(404)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(405)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 566 (M+H)⁺.

EXAMPLE 4(406)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 608 (M+H)⁺.

EXAMPLE 4(407)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(408)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(409)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(410)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(411)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(412)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(413)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(414)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(415)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺.

EXAMPLE 4(416)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(417)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(418)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(419)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(420)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(421)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(422)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(423)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.83 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(424)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(425)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(426)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(427)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(428)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(429)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 559 (M+H)⁺.

EXAMPLE 4(430)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(431)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(432)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(433)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 473 (M+H)⁺.

EXAMPLE 4(434)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 559 (M+H)⁺.

EXAMPLE 4(435)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.85 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(436)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(437)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(438)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(439)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

EXAMPLE 4(440)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺; HPLC retention time: 3.62 minutes;MASS data (ESI, Pos., 20V): 579 (M+H)⁺, 475.

EXAMPLE 4(441)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(442)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 559 (M+H)⁺.

EXAMPLE 4(443)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(444)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 594 (M+H)⁺.

EXAMPLE 4(445)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-methoxybenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(446)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 548 (M+H)⁺, 131.

EXAMPLE 4(447)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.03 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(448)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 558 (M+H)⁺.

EXAMPLE 4(449)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.72 minutes; MASSdata (ESI, Pos., 20V): 509 (M+H)⁺, 255.

EXAMPLE 4(450)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(451)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.07 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(452)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(453)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(454)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(455)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(456)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.38 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(457)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.98 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(458)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(459)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(460)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.00 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺, 201.

EXAMPLE 4(461)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(462)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(463)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 542 (M+H)⁺.

EXAMPLE 4(464)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.98 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(465)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(466)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 540 (M+H)⁺.

EXAMPLE 4(467)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.96 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺, 282; HPLC retention time: 3.07minutes; MASS data (ESI, Pos., 20V): 564 (M+H)⁺, 482, 282.

EXAMPLE 4(468)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(469)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.74 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺, 432, 269.

EXAMPLE 4(470)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.92 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺, 290, 267.

EXAMPLE 4(471)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(472)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(473)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(474)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(475)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(476)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(477)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(478)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(479)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(480)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(481)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(482)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(483)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(484)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(485)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(486)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(487)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(488)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(489)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺; HPLC retention time: 3.69 minutes;MASS data (ESI, Pos., 20V): 563 (M+H)⁺, 459.

EXAMPLE 4(490)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(491)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(492)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(493)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 578 (M+H)⁺.

EXAMPLE 4(494)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(495)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(496)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(497)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(498)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(499)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(500)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(501)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(502)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(503)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(504)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(505)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(506)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(507)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(508)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(509)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(510)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(511)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(512)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(513)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(514)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(515)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(516)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(517)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(518)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(519)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(520)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(521)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(522)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺; HPLC retention time: 3.66 minutes;MASS data (ESI, Pos., 20V): 593 (M+H)⁺, 489.

EXAMPLE 4(523)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(524)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(525)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 566 (M+H)⁺.

EXAMPLE 4(526)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 608 (M+H)⁺.

EXAMPLE 4(527)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(528)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 626 (M+H)⁺.

EXAMPLE 4(529)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 630 (M+H)⁺.

EXAMPLE 4(530)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.34 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺, 248.

EXAMPLE 4(531)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 612 (M+H)⁺.

EXAMPLE 4(532)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.59 minutes; MASSdata (ESI, Pos., 20V): 636 (M+H)⁺.

EXAMPLE 4(533)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.96 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(534)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.94 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(535)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 612 (M+H)⁺.

EXAMPLE 4(536)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 600 (M+H)⁺.

EXAMPLE 4(537)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.45 minutes; MASSdata (ESI, Pos., 20V): 586 (M+H)⁺.

EXAMPLE 4(538)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 616 (M+H)⁺.

EXAMPLE 4(539)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 600 (M+H)⁺.

EXAMPLE 4(540)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 616 (M+H)⁺.

EXAMPLE 4(541)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 620 (M+H)⁺.

EXAMPLE 4(542)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 616 (M+H)⁺.

EXAMPLE 4(543)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 600 (M+H)⁺.

EXAMPLE 4(544)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 600 (M+H)⁺.

EXAMPLE 4(545)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 614 (M+H)⁺.

EXAMPLE 4(546)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 642 (M+H)⁺.

EXAMPLE 4(547)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 642 (M+H)⁺.

EXAMPLE 4(548)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.29 minutes; MASSdata (ESI, Pos., 20V): 630 (M+H)⁺.

EXAMPLE 4(549)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.45 minutes; MASSdata (ESI, Pos., 20V): 604 (M+H)⁺.

EXAMPLE 4(550)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.45 minutes; MASSdata (ESI, Pos., 20V): 604 (M+H)⁺.

EXAMPLE 4(551)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 622 (M+H)⁺.

EXAMPLE 4(552)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 616 (M+H)⁺.

EXAMPLE 4(553)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 620 (M+H)⁺.

EXAMPLE 4(554)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 604 (M+H)⁺.

EXAMPLE 4(555)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(556)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 622 (M+H)⁺.

EXAMPLE 4(557)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 620 (M+H)⁺.

EXAMPLE 4(558)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 616 (M+H)⁺.

EXAMPLE 4(559)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 614 (M+H)⁺.

EXAMPLE 4(560)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 618 (M+H)⁺.

EXAMPLE 4(561)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 592 (M+H)⁺.

EXAMPLE 4(562)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 642 (M+H)⁺; HPLC retention time: 3.36 minutes;MASS data (ESI, Pos., 20V): 642 (M+H)⁺.

EXAMPLE 4(563)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 600 (M+H)⁺.

EXAMPLE 4(564)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 622 (M+H)⁺.

EXAMPLE 4(565)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.96 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺, 361.

EXAMPLE 4(566)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 657 (M+H)⁺, 403.

EXAMPLE 4(567)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-aminosulfonylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 600 (M+H)⁺.

EXAMPLE 4(568)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.21 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(569)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 619 (M+H)⁺.

EXAMPLE 4(570)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.21 minutes; MASSdata (ESI, Pos., 20V): 625 (M+H)⁺.

EXAMPLE 4(571)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.44 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(572)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.11 minutes; MASSdata (ESI, Pos., 20V): 589 (M+H)⁺.

EXAMPLE 4(573)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 575 (M+H)⁺.

EXAMPLE 4(574)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.11 minutes; MASSdata (ESI, Pos., 20V): 589 (M+H)⁺.

EXAMPLE 4(575)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.17 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(576)3-(N-((2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 605 (M+H)⁺.

EXAMPLE 4(577)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.17 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(578)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.34 minutes; MASSdata (ESI, Pos., 20V): 631 (M+H)⁺.

EXAMPLE 4(579)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.35 minutes; MASSdata (ESI, Pos., 20V): 631 (M+H)⁺.

EXAMPLE 4(580)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 619 (M+H)⁺.

EXAMPLE 4(581)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(582)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(583)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 605 (M+H)⁺.

EXAMPLE 4(584)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.15 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(585)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(586)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.21 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(587)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 605 (M+H)⁺.

EXAMPLE 4(588)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.22 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(589)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.15 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(590)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 631 (M+H)⁺; HPLC retention time: 3.93 minutes;MASS data (ESI, Pos., 20V): 631 (M+H)⁺, 527.

EXAMPLE 4(591)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.15 minutes; MASSdata (ESI, Pos., 20V): 589 (M+H)⁺.

EXAMPLE 4(592)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(593)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 604 (M+H)⁺.

EXAMPLE 4(594)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 646 (M+H)⁺.

EXAMPLE 4(595)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 589 (M+H)⁺.

EXAMPLE 4(596)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.01 minutes; MASSdata (ESI, Pos., 20V): 591 (M+H)⁺.

EXAMPLE 4(597)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(598)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(599)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(600)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(601)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 507 (M+H)⁺.

EXAMPLE 4(602)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(603)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(604)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(605)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(606)3-(N-((2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(607)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(608)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.15 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(609)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.19 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(610)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(611)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(612)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(613)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(614)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(615)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(616)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(617)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 583 (M+H)⁺.

EXAMPLE 4(618)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI Pos., 20V): 607 (M+H)⁺; HPLC retention time: 3.78 minutes;MASS data (ESI, Pos., 20V): 607 (M+H)⁺, 503.

EXAMPLE 4(619)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(620)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.96 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(621)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.29 minutes; MASSdata (ESI, Pos., 20V): 580 (M+H)⁺.

EXAMPLE 4(622)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 622 (M+H)⁺.

EXAMPLE 4(623)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(624)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(625)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(626)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(627)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(628)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 512 (M+H)⁺.

EXAMPLE 4(629)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 512 (M+H)⁺.

EXAMPLE 4(630)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(631)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(632)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 511 (M+H)⁺.

EXAMPLE 4(633)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(634)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(635)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(636)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 545 (M+H)⁺.

EXAMPLE 4(637)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(638)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(639)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(640)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(641)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(642)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(643)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(644)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

EXAMPLE 4(645)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

EXAMPLE 4(646)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(647)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(648)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 545 (M+H)⁺.

EXAMPLE 4(649)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

EXAMPLE 4(650)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 461 (M+H)⁺.

EXAMPLE 4(651)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(652)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 545 (M+H)⁺.

EXAMPLE 4(653)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(654)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(655)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(656)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 517 (M+H)⁺.

EXAMPLE 4(657)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺; HPLC retention time: 3.66 minutes;MASS data (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(658)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(659)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(660)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 540 (M+H)⁺.

EXAMPLE 4(661)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(662)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(4-fluorobenzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(663)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(664)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(665)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.01 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(666)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(667)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.29 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(668)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(669)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(670)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(671)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(672)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(673)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(674)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(675)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(676)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(677)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(678)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(679)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(680)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.21 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(681)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.22 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(682)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(683)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(684)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(685)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(686)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(687)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(688)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(689)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 471 (M+H)⁺.

EXAMPLE 4(690)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(691)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(692)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(693)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(694)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(695)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(696)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺; HPLC retention time: 3.77 minutes;MASS data (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(697)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.96 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(698)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(699)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(700)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 592 (M+H)⁺.

EXAMPLE 4(701)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methylphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(702)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(703)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(704)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(705)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(706)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(707)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(708)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(709)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(710)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(711)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(712)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(713)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(714)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(715)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(716)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(717)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(718)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(719)3-(N-((2-(2-((N-isopropyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(720)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(721)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.11 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(722)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(723)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(724)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(725)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(726)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(727)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(728)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(729)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(730)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 517 (M+H)⁺.

EXAMPLE 4(731)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(732)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(733)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(734)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(735)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(736)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(737)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺; HPLC retention time: 3.71 minutes;MASS data (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(738)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(739)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(740)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 596 (M+H)⁺.

EXAMPLE 4(741)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 638 (M+H)⁺.

EXAMPLE 4(742)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(743)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 621 (M+H)⁺.

EXAMPLE 4(744)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 625 (M+H)⁺.

EXAMPLE 4(745)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.63 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(746)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(747)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 631 (M+H)⁺.

EXAMPLE 4(748)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(749)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(750)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(751)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(752)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(753)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(754)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(755)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(756)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(757)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(758)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(759)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(760)3-(N-((2-(2-((N-isopropyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(761)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(762)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 637 (M+H)⁺, 388.

EXAMPLE 4(763)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 637 (M+H)⁺.

EXAMPLE 4(764)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 625 (M+H)⁺.

EXAMPLE 4(765)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(766)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(767)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(768)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(769)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(770)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(771)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 531 (M+H)⁺.

EXAMPLE 4(772)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(773)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(774)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(775)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(776)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 613 (M+H)⁺.

EXAMPLE 4(777)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(778)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 637 (M+H)⁺; HPLC retention time: 3.62 minutes;MASS data (ESI, Pos., 20V): 637 (M+H)⁺, 533.

EXAMPLE 4(779)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(780)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(781)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 610 (M+H)⁺, 596.

EXAMPLE 4(782)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 652 (M+H)⁺.

EXAMPLE 4(783)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxy-4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(784)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 621 (M+H)⁺.

EXAMPLE 4(785)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 625 (M+H)⁺.

EXAMPLE 4(786)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.67 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(787)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(788)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 631 (M+H)⁺.

EXAMPLE 4(789)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(790)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 582 (M+H)⁺.

EXAMPLE 4(791)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(792)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(793)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(794)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(795)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(796)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(797)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(798)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(799)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(800)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(801)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(802)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 637 (M+H)⁺, 388.

EXAMPLE 4(803)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 637 (M+H)⁺.

EXAMPLE 4(804)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 625 (M+H)⁺.

EXAMPLE 4(805)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(806)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(807)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(808)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(809)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(810)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(811)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 531 (M+H)⁺.

EXAMPLE 4(812)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(813)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 615 (M+H)⁺.

EXAMPLE 4(814)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(815)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 609 (M+H)⁺.

EXAMPLE 4(816)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 613 (M+H)⁺.

EXAMPLE 4(817)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(818)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.51 minutes; MASSdata (ESI, Pos., 20V): 637 (M+H)⁺; HPLC retention time: 3.66 minutes;MASS data (ESI, Pos., 20V): 637 (M+H)⁺, 533.

EXAMPLE 4(819)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(820)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(821)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 610 (M+H)⁺.

EXAMPLE 4(822)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.42 minutes; MASSdata (ESI, Pos., 20V): 652 (M+H)⁺.

EXAMPLE 4(823)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxy-4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(824)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(825)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(826)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(827)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(828)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 617 (M+H)⁺.

EXAMPLE 4(829)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(830)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 568 (M+H)⁺.

EXAMPLE 4(831)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(832)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(833)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(834)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(835)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(836)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(837)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(838)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(839)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(840)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(841)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenylphenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(842)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(843)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.11 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺.

EXAMPLE 4(844)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(845)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(846)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(847)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(848)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(849)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(850)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(851)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 517 (M+H)⁺.

EXAMPLE 4(852)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(853)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(854)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 597 (M+H)⁺.

EXAMPLE 4(855)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(856)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 599 (M+H)⁺.

EXAMPLE 4(857)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(858)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 623 (M+H)⁺; HPLC retention time: 3.67 minutes;MASS data (ESI, Pos., 20V): 623 (M+H)⁺, 519.

EXAMPLE 4(859)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(860)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 603 (M+H)⁺.

EXAMPLE 4(861)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 596 (M+H)⁺.

EXAMPLE 4(862)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.47 minutes; MASSdata (ESI, Pos., 20V): 638 (M+H)⁺.

EXAMPLE 4(863)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3,5-dimethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(864)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 591 (M+H)⁺.

EXAMPLE 4(865)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(866)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺, 489.

EXAMPLE 4(867)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(868)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(869)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.36 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(870)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.31 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(871)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(872)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(873)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(874)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(875)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(876)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(877)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(878)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(879)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(880)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(881)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(882)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.24 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(883)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.28 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(884)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.79 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(885)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(886)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(887)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(888)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(889)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(890)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(891)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 501 (M+H)⁺.

EXAMPLE 4(892)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(893)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(894)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(895)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(896)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 583 (M+H)⁺.

EXAMPLE 4(897)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(898)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.66 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺; HPLC retention time: 3.82 minutes;MASS data (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(899)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(900)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(901)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.36 minutes; MASSdata (ESI, Pos., 20V): 580 (M+H)⁺.

EXAMPLE 4(902)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 622 (M+H)⁺.

EXAMPLE 4(903)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(904)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 591 (M+H)⁺.

EXAMPLE 4(905)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(906)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(907)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(908)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(909)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(910)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 552 (M+H)⁺.

EXAMPLE 4(911)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(912)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(913)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(914)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(915)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(916)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(917)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(918)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(919)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(920)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(921)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(922)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.19 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(923)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.22 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(924)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.71 minutes; MASSdata (ESI, Pos., 20V): 595 (M+H)⁺.

EXAMPLE 4(925)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(926)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(927)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(928)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(929)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(930)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(931)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 501 (M+H)⁺.

EXAMPLE 4(932)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(933)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 585 (M+H)⁺.

EXAMPLE 4(934)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(935)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(936)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 583 (M+H)⁺.

EXAMPLE 4(937) 3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(938)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 607 (M+H)⁺; HPLC retention time: 3.77 minutes;MASS data (ESI, Pos., 20V): 607 (M+H)⁺.

EXAMPLE 4(939)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(940)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(941)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 580 (M+H)⁺.

EXAMPLE 4(942)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.53 minutes; MASSdata (ESI, Pos., 20V): 622 (M+H)⁺.

EXAMPLE 4(943)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(944)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(945)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(946)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(947)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.33 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(948)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(949)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(950)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(951)3-(N-((2-(2-((N-isopropyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(952)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(953)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.19 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(954)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.19 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(955)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(956)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(957)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(958)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(959)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(960)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(961)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(962)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(963)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺; HPLC retention time: 3.75 minutes;MASS data (ESI, Pos., 20V): 577 (M+H)⁺, 473.

EXAMPLE 4(964)3-(N-((2-(2-((3-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(965)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.31 minutes; MASSdata (ESI, Pos., 20V): 550 (M+H)⁺.

EXAMPLE 4(966)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.55 minutes; MASSdata (ESI, Pos., 20V): 592 (M+H)⁺.

EXAMPLE 4(967)3-(N-((2-(2-((1,2,3,4-tetrahydro-1-naphthylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 533 (M+H)⁺.

EXAMPLE 4(968)3-(N-((2-(2-((N-benzyl-N-(2-hydroxyethyl)amino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(969)3-(N-((2-(2-((1-naphthylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(970)3-(N-((2-(2-((α-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 507 (M+H)⁺.

EXAMPLE 4(971)3-(N-((2-(2-((2-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 507 (M+H)⁺.

EXAMPLE 4(972)3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(973)3-(N-((2-(2-((N-ethyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(974)3-(N-((2-(2-((N-butyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(975)3-(N-((2-(2-((4-(tert-butyl)benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(976)3-(N-((2-(2-((1-phenyl-3-hydroxypropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(977)3-(N-((2-(2-((2,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

EXAMPLE 4(978)3-(N-((2-(2-(((1R)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.56 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺.

EXAMPLE 4(979)3-(N-((2-(2-((2-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(980)3-(N-((2-(2-((3-chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(981)3-(N-((2-(2-(((1S)-1-phenyl-2-hydroxyethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺.

EXAMPLE 4(982)3-(N-((2-(2-(((1R)-1-(4-methylphenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(983)3-(N-((2-(2-((1-(4-fluorophenyl)ethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(984)3-(N-((2-(2-(((3S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.49 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺; HPLC retention time: 3.62 minutes;MASS data (ESI, Pos., 20V): 549 (M+H)⁺, 445.

EXAMPLE 4(985)3-(N-((2-(2-((N-methyl-N-(6-methylpyridin-2-yl)methylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺, 508.

EXAMPLE 4(986)3-(N-((2-(2-((N-(2-(N,N-dimethylamino)ethyl)-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.40 minutes; MASSdata (ESI, Pos., 20V): 564 (M+H)⁺.

EXAMPLE 4(987)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)-4-methylphenyl)-5-methylphenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: B HPLC retention time: 3.59 minutes; MASSdata (ESI, Pos.): 580 (M+H)⁺, 472.

EXAMPLE 4(988)3-(N-((2-(2-((1-methyl-3-phenylpropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 579 (M+H)⁺.

EXAMPLE 4(989)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)-4-methylphenyl)-5-methylphenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: B HPLC retention time: 4.53 minutes; MASSdata (ESI, Pos.): 597 (M+H)⁺, 525.

EXAMPLE 4(990)3-(N-((2-(2-((1-methyl-3-phenylpropylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(991)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(992)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(993)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.23 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(994)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(995)3-(N-((2-(2-((pyridin-4-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.2 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(996)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 563 (M+H)⁺.

EXAMPLE 4(997)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.8 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(998)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(999)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1000)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (+H)⁺.

EXAMPLE 4(1001)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1002)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(1003)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(1004)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.64 minutes; MASSdata (ESI, Pos., 20V): 995 (2M+Na)⁺, 487 (M+H)⁺.

EXAMPLE 4(1005)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(1006)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(3-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(1007)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.03 minutes; MASSdata (ESI, Pos., 20V): 967 (2M+H)⁺, 484 (M+H)⁺.

EXAMPLE 4(1008)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 520 (M+H)⁺.

EXAMPLE 4(1009)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.21 minutes; MASSdata (ESI, Pos., 20V): 520 (M+H)⁺.

EXAMPLE 4(1010)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(1011)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(1012)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 524 (M+H)⁺.

EXAMPLE 4(1013)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(1014)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(1015)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.10 minutes; MASSdata (ESI, Pos., 20V): 512 (M+H)⁺.

EXAMPLE 4(1016)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 512 (M+H)⁺.

EXAMPLE 4(1017)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 512 (M+H)⁺.

EXAMPLE 4(1018)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.94 minutes; MASSdata (ESI, Pos., 20V): 887 (2M+H)⁺, 444 (M+H)⁺.

EXAMPLE 4(1019)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 530 (M+H)⁺.

EXAMPLE 4(1020)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(pyridin-3-ylmethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 500 (M+H)⁺.

EXAMPLE 4(1021)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺.

EXAMPLE 4(1022)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.72 minutes; MASSdata (ESI, Pos., 20V): 509 (M+H)⁺, 255.

EXAMPLE 4(1023)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.72 minutes; MASSdata (ESI, Pos., 20V): 509 (M+H)⁺, 255.

EXAMPLE 4(1024)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺.

EXAMPLE 4(1025)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.13 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(1026)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(1027)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(1028)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(1029)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.22 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(1030)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(1031)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(1032)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 526 (M+H)⁺.

EXAMPLE 4(1033)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.94 minutes; MASSdata (ESI, Pos., 20V): 458 (M+H)⁺.

EXAMPLE 4(1034)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(1035)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 514 (M+H)⁺.

EXAMPLE 4(1036)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(1037)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-2-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(1038)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(1039)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.02 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(1040)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.38 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(1041)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.27 minutes; MASSdata (ESI, Pos., 20V): 536 (M+H)⁺.

EXAMPLE 4(1042)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 561 (M+H)⁺.

EXAMPLE 4(1043)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(1044)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(1045?3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(1046)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(1047)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.00 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(1048)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 549 (M+H)⁺.

EXAMPLE 4(1049)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.97 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(1050)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 553 (M+H)⁺.

EXAMPLE 4(1051)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 485 (M+H)⁺.

EXAMPLE 4(1052)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 571 (M+H)⁺.

EXAMPLE 4(1053)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(1-methyl-3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(1054)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1055)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1056)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1057)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1058)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺, 537.

EXAMPLE 4(1059)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(1060)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(1061)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.69 minutes; MASSdata (ESI, Pos., 20V): 487 (M+H)⁺.

EXAMPLE 4(1062)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 573 (M+H)⁺.

EXAMPLE 4(1063)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1064)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.01 minutes; MASSdata (ESI, Pos., 20V): 498 (M+H)⁺.

EXAMPLE 4(1065)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺, 418.

EXAMPLE 4(1066)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.70 minutes; MASSdata (ESI, Pos., 20V): 509 (M+H)⁺, 255.

EXAMPLE 4(1067)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.20 minutes; MASSdata (ESI, Pos., 20V): 534 (M+H)⁺.

EXAMPLE 4(1068)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(1069)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.11 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(1070)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 538 (M+H)⁺.

EXAMPLE 4(1071)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(1072)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.16 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(1073)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 2.92 minutes; MASSdata (ESI, Pos., 20V): 915 (2M+H)⁺, 458 (M+H)⁺.

EXAMPLE 4(1074)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.09 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺, 272.

EXAMPLE 4(1075)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 544 (M+H)⁺.

EXAMPLE 4(1076)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(pyridin-4-yl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.14 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺, 261.

EXAMPLE 4(1077)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 533 (M+H)⁺.

EXAMPLE 4(1078)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 508 (M+H)⁺.

EXAMPLE 4(1079)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 533 (M+H)⁺.

EXAMPLE 4(1080)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(1081)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(1082)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 537 (M+H)⁺.

EXAMPLE 4(1083)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(1084)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenylcarbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(1085)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(1086)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(1087)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.62 minutes; MASSdata (ESI, Pos., 20V): 457 (M+H)⁺.

EXAMPLE 4(1088)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 543 (M+H)⁺.

EXAMPLE 4(1089)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-phenylethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 513 (M+H)⁺.

EXAMPLE 4(1090)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1091)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1092)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.75 minutes; MASSdata (ESI, Pos., 20V): 567 (M+H)⁺.

EXAMPLE 4(1093)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1094)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1095)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 555 (M+H)⁺.

EXAMPLE 4(1096)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-methoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.60 minutes; MASSdata (ESI, Pos., 20V): 487 (M+H)⁺.

EXAMPLE 4(1097)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.15 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(1098)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.34 minutes; MASSdata (ESI, Pos., 20V): 576 (M+H)⁺.

EXAMPLE 4(1099)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.10 minutes; MASSdata (ESI, Pos., 20V): 601 (M+H)⁺.

EXAMPLE 4(1100)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 605 (M+H)⁺.

EXAMPLE 4(1101)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 605 (M+H)⁺.

EXAMPLE 4(1102)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.13 minutes; MASSdata (ESI, Pos., 20V): 589 (M+H)⁺.

EXAMPLE 4(1103)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.08 minutes; MASSdata (ESI, Pos., 20V): 589 (M+H)⁺.

EXAMPLE 4(1104)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.06 minutes; MASSdata (ESI, Pos., 20V): 593 (M+H)⁺.

EXAMPLE 4(1105)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 525 (M+H)⁺.

EXAMPLE 4(1106)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 611 (M+H)⁺.

EXAMPLE 4(1107)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(2,4-dichlorophenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 4.04 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(1108)3-(N-((2-(2-((2-furylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.80 minutes; MASSdata (ESI, Pos., 20V): 541 (M+H)⁺.

EXAMPLE 4(1109)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(1110)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 577 (M+H)⁺.

EXAMPLE 4(1111)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(1112)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.87 minutes; MASSdata (ESI, Pos., 20V): 581 (M+H)⁺.

EXAMPLE 4(1113)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(1114)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 565 (M+H)⁺.

EXAMPLE 4(1115)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(1116)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(1117)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 569 (M+H)⁺.

EXAMPLE 4(1118)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 501 (M+H)⁺.

EXAMPLE 4(1119)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 587 (M+H)⁺.

EXAMPLE 4(1120)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(2-(4-ethoxyphenyl)ethyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(1121)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(1122)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.25 minutes; MASSdata (ESI, Pos., 20V): 522 (M+H)⁺.

EXAMPLE 4(1123)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 547 (M+H)⁺.

EXAMPLE 4(1124)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 521 (M+H)⁺.

EXAMPLE 4(1125)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1126)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1127)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 551 (M+H)⁺.

EXAMPLE 4(1128)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(1129)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(1130)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.89 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(1131)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.93 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(1132)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.91 minutes; MASSdata (ESI, Pos., 20V): 539 (M+H)⁺.

EXAMPLE 4(1133)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 963 (2M+Na)⁺, 471 (M+H)⁺.

EXAMPLE 4(1134)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.88 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(1135)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 527 (M+H)⁺.

EXAMPLE 4(1136)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.99 minutes; MASSdata (ESI, Pos., 20V): 557 (M+H)⁺.

EXAMPLE 4(1137)3-(N-((2-(2-((2-phenylethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(3-phenylpropyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.95 minutes; MASSdata (ESI, Pos., 20V): 535 (M+H)⁺.

EXAMPLE 4(1138)3-(N-((2-(2-((1-indaneamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 519 (M+H)⁺.

EXAMPLE 4(1139)3-(N-((2-(2-((pyridin-2-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.18 minutes; MASSdata (ESI, Pos., 20V): 987 (2M+H)⁺, 494 (M+H)⁺.

EXAMPLE 4(1140)3-(N-((2-(2-((pyridin-3-ylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.12 minutes; MASSdata (ESI, Pos., 20V): 987 (2M+H)⁺, 494 (M+H)⁺.

EXAMPLE 4(1141)3-(N-((2-(2-((1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.82 minutes; MASSdata (ESI, Pos., 20V): 519 (M+H)⁺.

EXAMPLE 4(1142)3-(N-((2-(2-((benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 985 (2M+H)⁺, 493 (M+H)⁺.

EXAMPLE 4(1143)3-(N-((2-(2-((2-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺.

EXAMPLE 4(1144)3-(N-((2-(2-((3-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺.

EXAMPLE 4(1145)3-(N-((2-(2-((4-methoxybenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 523 (M+H)⁺.

EXAMPLE 4(1146)3-(N-((2-(2-((4-methylbenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.84 minutes; MASSdata (ESI, Pos., 20V): 507 (M+H)⁺.

EXAMPLE 4(1147)3-(N-((2-(2-((N-methyl-N-benzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 507 (M+H)⁺, 493.

EXAMPLE 4(1148)3-(N-((2-(2-((2-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 511 (+H)⁺.

EXAMPLE 4(1149)3-(N-((2-(2-((3-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.78 minutes; MASSdata (ESI, Pos., 20V): 511 (M+H)⁺.

EXAMPLE 4(1150)3-(N-((2-(2-((4-fluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.77 minutes; MASSdata (ESI, Pos., 20V): 511 (M+H)⁺.

EXAMPLE 4(1151)3-(N-((2-(2-((allylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.58 minutes; MASSdata (ESI, Pos., 20V): 907 (2M+Na)⁺, 443 (M+H)⁺.

EXAMPLE 4(1152)3-(N-((2-(2-((2,6-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

EXAMPLE 4(1153)3-(N-((2-(2-((2-thienylmethylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.73 minutes; MASSdata (ESI, Pos., 20V): 997 (2M+H)⁺, 499 (M+H)⁺.

EXAMPLE 4(1154)3-(N-((2-(2-((3,5-difluorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-N-(benzyl)amino)propanoicacid

HPLC measurement condition: A HPLC retention time: 3.86 minutes; MASSdata (ESI, Pos., 20V): 529 (M+H)⁺.

BIOLOGICAL EXAMPLE

The antagonistic activity of the compound against LPA receptor in thepresent invention was proved by experiment shown in the following. Forexample, the antagonistic activity of the compounds against EDG-2 wasproved by experiment shown in the following.

A series of the procedure is based on the basic gene manipurationtechnique, that is gene overexpressed cells are prepared and aconventional method was utilized. In addition, the method for theevaluation of compounds in the present invention is improved on theusual method making enhancement of measurement precision and/ormeasurement sensitivity as follows. A detailed method of the experimentwas shown in the following clause.

Evaluation of EDG-2 Antagonistic Activity by Monitoring the Change ofIntracellular Calcium Ion Concentration

Evaluation of EDG-2 antagonistic activity was carried out by usingChinese hamster ovary (CHO) cells which overexpressed human EDG-2 gene.Those cells were cultured with Ham's F12 medium (GIBCO BRL companyNo.11765-047) containing 10% FBS (fetal bovine serum),penicillin/streptomycin and blasticidin (5 μg/ml). At first in order touptake Fura2-AM (Dojindo company No.348-05831) into the cells cells,cells were incubated for 60 minutes at 37 degrees in Fura2-AM (5 μM)solution [Ham's F12 medium containing 10% FBS, 20 mM HEPES buffer (pH7.4) and 2.5 mM probenecid (Sigma company No.P-8761)]. Next, it waswashed with Hanks solution containing HEPES buffer (20 mM, pH 7.4) andprobenecid (2.5 mM) once, and immersed into the Hanks solution. Plateswere set in fluorescent drug screening system (Hamamatsu photonicscompany, FDSS-2000) and intracellular calcium ion concentration wasmeasured for 30 seconds with no stimulation and then solution of thecompound of the present invention represented by formula (I) was added.Five minutes after adding thereto LPA (final concentration: 100 nM) wasadded, the increase of intracellular calcium ion concentrations beforeand after the addition of LPA (excitation wave length: 340 nM and 380nM; fluorescent wave length: 500 nm) were measured every 3 seconds. Thecompound of the present invention represented by the formula (I) wasdissolved in dimethyl sulfoxide (DMSO), and it was added so that thefinal concentration became 1 nM to 10 μM. 1-linolenoyl (18:3)-LPA wasused as LPA. 1-linolenoyl (18:3)-LPA was synthesized from (18:3)-LPC(linolenoyl (18:3)-lysophosphatidylcholine) (Sedary company) by PLD(phospholipase D).

EDG-2 antagonistic activity was calculated as an inhibition rate (%) bythe following equation, wherein the peak value of LPA (finalconcentration: 100 nM) in a well into which DMSO containing no testcompound represented by the formula (I) was added was regarded as acontrol value (A), and in the cells treated with the test compound thedifference (B) between the value before addition of the test compoundand that after the addition was obtained and compared with the controlvalue.Inhibition rate(%)=[(A−B)/A]×100

The IC₅₀ value was calculated as a concentration of the compound to betested which showed 50% inhibition.

Experimental result for the compound of the present invention in Example3 and Example 3(1) are shown in table 1.

TABLE 1 Example number IC₅₀ (μmol/L) Example 3 0.41 Example 3(1) 0.78

FORMULATION EXAMPLE 1

The following components were admixed in a conventional manner, punchedout to give 100 tablets each containing 50 mg of active ingredient.

3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)car- 5.0 gbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoic acid carciumcarboxymethyl cellulose (disintegrant) 0.2 g magnesium stearate(lubricant) 0.1 g microcrystalline cellulose 4.7 g

FORMULATION EXAMPLE 2

The following components were admixed in a conventional technique. Thesolution was sterilized in a conventional technique, filled in ampoules5 ml each and freeze-dried over in a conventional technique to give 100ampoules each containing 20 mg of active ingredient.

3-(N-((2-(2-((4-chlorobenzylamino)carbonyl)phenyl)phenyl)- 2.0 gcarbonyl)-N-(2-(2,5-dimethoxyphenyl)ethyl)amino)propanoic acid mannitol20 g distilled water 1000 mL

1. A β-alanine derivative represented by formula (I):

wherein A represents (1) C1˜6 alkylene, (2) C2˜6 alkenylene, or (3) C2˜6alkynylene wherein A may be substituted by 1-3 of C1˜4 alkyl;

 represents (1) C3˜15 carbocyclic ring, or (2) 3-15 memberedheterocyclic ring containing 1-4 of nitrogen atom(s), 1-2 of oxygenatom(s) and/or 1-2 of sulfur atom(s); R¹ represents (1) C1˜4 alkyl, (2)a halogen atom, (3) cyano, (4) trihalomethyl, (5) —OR⁶, (6) —SR⁷, (7)—NR⁸R⁹, (8) nitro, (9) —COOR¹⁰, (10) —CONR¹¹R¹², (11) —NR¹³COR¹⁴, (12)—SO₂NR¹⁵R¹⁶, (13) —NR¹⁷SO₂R¹⁸, (14) —S(O)R¹⁹ or (15) —SO₂R²⁰; R⁶, R⁷,R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹ and R²⁰ eachindependently represents (1) a hydrogen atom or (2) C1˜4 alkyl; R² andR³ each independently represents (1) C1˜4 alkyl, (2) C1˜4 alkoxy or (3)a halogen atom; R⁴ and R⁵ each independently represents (1) a hydrogenatom, (2) C1˜4 alkyl, (3) C2˜4 alkenyl, (4) C2˜4 alkynyl, (5) C1˜4 alkylsubstituted by —OR²¹, (6) C1˜4 alkyl substituted by —NR²²R²³ or (7)

R⁴ and R⁵ taken together with nitrogen atom to which they are attachedrepresents 3-15 membered mono-, bi- or tricyclic heterocyclic ringwherein the heterocyclic ring contains at least one nitrogen atom andmay be substituted by C1˜4 alkyl substituted by —OR²⁵; R²¹, R²², R²³ andR²⁵ each independently represents (1) a hydrogen atom, (2) C1˜4 alkyl(3) C2˜6 acyl or (4) trihaloacetyl; E represents (1) single bond, (2)C1˜6 alkylene, (3) C2˜6 alkenylene or (4) C2˜6 alkynylene wherein E maybe substituted by C1˜4 alkyl substituted by 1-3 of group(s) selectedfrom (1) C1˜4 alkyl and (2) —OR²⁶; R²⁶ represents (1) a hydrogen atom,(2) C1˜4 alkyl, (3) C2˜6 acyl or (4) trihaloacetyl;

 represents (1) C3˜15 carbocyclic ring or (2) 3-15 membered heterocyclicring containing 1-4 of nitrogen atom(s), 1-2 of oxygen atom(s) and/or1-2 of sulfur atom(s); R²⁴ represents (1) C1˜4 alkyl, (2) a halogenatom, (3) cyano, (4) trihalomethyl, (5) —OR²⁷, (6) —SR²⁸, (7) —NR²⁹R³⁰,(8) nitro, (9) —COOR³¹, (10) —CONR³²R³³, (11) —NR³⁴COR³⁵, (12)—SO₂NR³⁶R³⁷, (13) —R³⁸SO₂R³⁹, (14) —S(O)R⁴⁰ or (15) —SO₂R⁴¹; R²⁷, R²⁸,R²⁹, R³⁰, R³¹, R³², R³³, R³⁴, R³⁵, R³⁶, R³⁷, R³⁸, R³⁹, R⁴⁰ and R⁴¹ eachindependently represents (1) a hydrogen atom or (2) C1˜4 alkyl; irepresents 0 or an integer of 1˜5; m represents 0 or an integer of 1˜4;n represents 0 or an integer of 1˜4; p represents 0 or an integer of1˜5; wherein when i is 2 or more, plural R¹ are the same or different;when m is 2 or more, plural R² are the same or different; when n is 2 ormore, plural R³ are the same or different; when p is 2 or more, pluralR²⁴ are the same or different, or a prodrug thereof or a salt thereof;wherein said prodrug is selected from the group consisting of thecompound of formulas (IA), (IB) and (IC):

wherein R⁴² represents (1) C1˜8 alkyl or (2) C1˜8 alkyl substituted by1-2 of hydroxyl or amino;

wherein R⁴³ and R⁴⁴ each independently represents (1) a hydrogen atom,(2) C1˜8 alkyl or (3) C1˜8 alkyl substituted by 1-2 of hydroxyl oramino;


2. The prodrug according to claim 1, which is represented by the formula(IA).
 3. The prodrug according to claim 1, which is represented by theformula (IB).
 4. The prodrug according to claim 1, which is representedby the formula (IC).
 5. A pharmaceutical composition comprising thecompounds according to claim 1, or the prodrug thereof or the saltthereof and a pharmaceutically acceptable carrier.